Edinyĭ Iu G, Dziurak V S, Zheltovskaia N I
Urol Nefrol (Mosk). 1989 Nov-Dec(6):37-40.
A study was made of urinary proteolysis. This parameter turned to be decreased in patients with nephrolithiasis versus normal subjects. The authors developed an original proteoclastic-ion theory of nephrolithiasis pathogenesis, based on the two main risk factors triggering the disease: low levels of urinary proteolysis leading to the formation of a calculous matrix; the urine pH values optimal for the sedimentation of lithiasic salts. The combination of both risk factors was responsible for the development of calculous crisis and the formation of microlith. The decreased index of urinary proteolysis calculated with the formula offered could be regarded as a risk indication to the microlith formation. A possible elimination of the both risk factors was demonstrated. The technique of microlithiasis metaphylaxis was developed with regard to the major and minor risk factors and the possibility of their elimination. The values of urinary proteolysis were the criteria for a successful therapeutic response. With regard to the number of risk factors the risk of primary nephrolithiasis or lithiasis relapses could be predicted.
对尿蛋白水解进行了一项研究。结果发现，与正常受试者相比，肾结石患者的这一参数有所降低。作者基于引发该疾病的两个主要风险因素，提出了一种关于肾结石发病机制的原始蛋白水解离子理论：尿蛋白水解水平低导致结石基质形成；尿液pH值有利于结石盐沉淀。这两个风险因素的结合导致了结石危机的发展和微结石的形成。用所提供公式计算出的尿蛋白水解指数降低可被视为微结石形成的风险指标。已证明有可能消除这两个风险因素。针对主要和次要风险因素及其消除可能性，开发了微结石病预防技术。尿蛋白水解值是治疗反应成功的标准。根据风险因素的数量，可以预测原发性肾结石或结石复发的风险。
