血管生成素-1和-2作为肠出血性大肠杆菌所致溶血尿毒综合征疾病严重程度的标志物
Angiopoietin-1 and -2 as markers for disease severity in hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli.
作者信息
Shimizu Masaki, Inoue Natsumi, Kuroda Mondo, Mizuta Mao, Sugimoto Naotoshi, Kaneda Hisashi, Ohta Kazuhide, Yachie Akihiro
机构信息
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
Department of Physiology, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
出版信息
Clin Exp Nephrol. 2017 Feb;21(1):76-82. doi: 10.1007/s10157-016-1254-z. Epub 2016 Mar 5.
BACKGROUND
Angiopoietin (Ang)-1 and -2 play important roles in maintaining vascular homeostasis. This study aimed to assess the roles of angiopoietin (Ang)-1 and -2 and to investigate the clinical significance of their serum levels in patients with hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli (EHEC).
METHODS
Twenty patients with HUS and 15 healthy controls were studied. Serum Ang-1 and Ang-2 levels were quantified using enzyme-linked immunosorbent assay. The results were compared with the clinical features of HUS.
RESULTS
During the HUS phase, serum Ang-1 levels were significantly decreased, whereas serum Ang-2 levels and the Ang-2/Ang-1 ratio were significantly elevated. Compared with patients without encephalopathy, serum Ang-2 levels and Ang-2/Ang-1 ratio were significantly elevated in patients with encephalopathy. Patients with HUS and serum Ang-2 levels of >7061 pg/mL or Ang2/Ang1 ratios of >2.29 were at high risk of encephalopathy. Serum Ang-1 levels were significantly decreased in patients in the pre-HUS phase compared with those in healthy controls.
CONCLUSION
Disruption of homeostasis of vascular endothelial function by Ang-1 and -2 may be closely associated with the development of HUS. Serum Ang-1 and -2 levels and the Ang-2/Ang-1 ratio may be promising indicators of disease activity in HUS and the development of encephalopathy.
背景
血管生成素（Ang）-1和-2在维持血管稳态中发挥重要作用。本研究旨在评估血管生成素（Ang）-1和-2的作用，并探讨其血清水平在肠出血性大肠杆菌（EHEC）诱导的溶血尿毒综合征（HUS）患者中的临床意义。
方法
对20例HUS患者和15名健康对照者进行研究。采用酶联免疫吸附测定法对血清Ang-1和Ang-2水平进行定量。将结果与HUS的临床特征进行比较。
结果
在HUS阶段，血清Ang-1水平显著降低，而血清Ang-2水平和Ang-2/Ang-1比值显著升高。与无脑病的患者相比，有脑病的患者血清Ang-2水平和Ang-2/Ang-1比值显著升高。HUS患者且血清Ang-2水平>7061 pg/mL或Ang2/Ang1比值>2.29者发生脑病的风险较高。与健康对照者相比，HUS前期患者的血清Ang-1水平显著降低。
结论
Ang-1和-2破坏血管内皮功能稳态可能与HUS的发生密切相关。血清Ang-1和-2水平以及Ang-2/Ang-1比值可能是HUS疾病活动和脑病发生的有前景的指标。
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