Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Cytokine. 2014 Mar;66(1):1-6. doi: 10.1016/j.cyto.2013.12.005. Epub 2013 Dec 31.
Proinflammatory cytokines are related to the pathogenesis of enterohemorrhagic Escherichia coli infection and hemolytic-uremic syndrome (HUS). We employed an antibody array that simultaneously detects 174 serum cytokines. We identified five serum biomarkers, namely insulin growth factor-binding protein-2, angiopoietin-2, soluble interleukin-6 receptor, soluble tumor necrosis factor receptor type II, and matrix metalloprotease protein-3 whose levels increased with the development of HUS. Furthermore, the levels of these cytokines were significantly increased in severe HUS compared with mild HUS. These cytokines might play an important role in the pathogenesis of HUS and may also be used to predict the severity of HUS.
促炎细胞因子与肠出血性大肠杆菌感染和溶血尿毒综合征（HUS）的发病机制有关。我们采用了一种抗体芯片，可以同时检测 174 种血清细胞因子。我们鉴定出了 5 种血清生物标志物，即胰岛素样生长因子结合蛋白-2、血管生成素-2、可溶性白细胞介素-6 受体、可溶性肿瘤坏死因子受体 II 型和基质金属蛋白酶-3，它们的水平随着 HUS 的发展而升高。此外，与轻度 HUS 相比，这些细胞因子在严重 HUS 中的水平显著升高。这些细胞因子可能在 HUS 的发病机制中起重要作用，也可能用于预测 HUS 的严重程度。
