The Graduate School, University of Santo Tomas, España Blvd., Manila 1015, Philippines.
J Ethnopharmacol. 2016 May 26;184:18-21. doi: 10.1016/j.jep.2016.03.002. Epub 2016 Mar 3.
Eclipta alba, also known as Eclipta prostrata, is a weed of the family Asteraceae found in tropical and subtropical regions widely used in herbal medicine, including treatment of renal diseases.
This study aims to evaluate the protective effect of the methanolic leaf extract of Eclipta alba on gentamicin-induced nephrotoxicity in rats.
Nephrotoxicity was induced in rats by subcutaneous injection of gentamicin (80mg/kg/day for seven days). Quercetin was used as a positive control. The nephroprotective activity was evaluated by determining blood urea nitrogen, serum creatinine, urinary microprotein, renal catalase and malondialdehyde levels.
The extract protected the rat kidneys against gentamicin-induced renal tubular alterations and rises in blood urea nitrogen, serum creatinine, and microprotein levels. Lipid peroxidation and decrement in catalase levels were also ameliorated.
The study revealed the protective effect of the methanolic leaf extract of E. alba and suggests that the probable mechanism for the nephroprotection by the extract may be due to its good radical scavenging activity and Fe(3+) ion-reducing ability.
墨旱莲，又名鳢肠，是菊科杂草，广泛存在于热带和亚热带地区，在草药医学中被用于治疗肾病等疾病。
本研究旨在评估墨旱莲甲醇叶提取物对庆大霉素诱导的大鼠肾毒性的保护作用。
通过皮下注射庆大霉素（80mg/kg/天，持续 7 天）诱导大鼠产生肾毒性。槲皮素用作阳性对照。通过测定血尿素氮、血清肌酐、尿微量蛋白、肾过氧化氢酶和丙二醛水平来评估肾保护活性。
该提取物可防止大鼠肾脏因庆大霉素引起的肾小管改变以及血尿素氮、血清肌酐和微量蛋白水平升高。脂质过氧化和过氧化氢酶水平下降也得到了改善。
本研究揭示了墨旱莲甲醇叶提取物的保护作用，并表明提取物的肾保护作用可能与其良好的自由基清除活性和 Fe(3+)离子还原能力有关。
