Ehsani Vahid, Amirteimoury Morteza, Taghipour Zahra, Shamsizadeh Ali, Bazmandegan Gholamreza, Rahnama Amir, Khajehasani Fatemeh, Fatemi Iman
a Physiology-Pharmacology Research Center , Rafsanjan University of Medical Sciences , Rafsanjan , Iran.
b Department of Anatomy, School of Medicine , Rafsanjan University of Medical Sciences , Rafsanjan , Iran.
Ren Fail. 2017 Nov;39(1):519-525. doi: 10.1080/0886022X.2017.1326384.
Pistacia vera is a plant of the family Anacardiaceae found in Central and West Asia. P. vera nut (Pistachio) possess multiple pharmacological effects such as antimicrobial, anti-hyperlipidemia, antioxidant and anti-inflammatory. This study is designed to evaluate the protective effect of the hydroalcoholic extract of pistachio on gentamicin-induced nephrotoxicity in rats.
Nephrotoxicity was induced in rats by intraperitoneal injection of gentamicin (100 mg/kg/day for 7 days). Hydroalcoholic extract of pistachio (10, 50 and 100 mg/kg/p.o) was administered for 7 days. The nephroprotective activity was evaluated by determining creatinine clearance, serum creatinine, urine volume, urine glucose and blood urea nitrogen (BUN) levels. The kidneys were processed for histopathological examinations and all specimens were examined for morphologic parameters involving tubular degeneration, tubular necrosis and tubule interstitial nephritis.
Results showed a significant increase in the levels of serum creatinine, urine volume, urine glucose and BUN and decrease of creatinine clearance by gentamicin (GA) administration. Co-administration with pistachio extract showed reduction in the levels of serum creatinine, urine volume, urine glucose and BUN and increase of creatinine clearance in all doses but the most significant alteration was observed in doses of 100 mg/kg. Also, the nephroprotective effect of the GA was confirmed by the histological examination of the kidneys.
The study revealed the nephroprotective effect of the hydroalcoholic extract of pistachio. These findings suggest that pistachio treatment may attenuate renal dysfunction and structural damage through the reduction of oxidative stress and inflammation in the kidney.
阿月浑子是一种漆树科植物，生长于中亚和西亚地区。阿月浑子坚果（开心果）具有多种药理作用，如抗菌、抗高血脂、抗氧化和抗炎作用。本研究旨在评估开心果水醇提取物对庆大霉素诱导的大鼠肾毒性的保护作用。
通过腹腔注射庆大霉素（100mg/kg/天，共7天）诱导大鼠肾毒性。给予开心果水醇提取物（10、50和100mg/kg/口服）7天。通过测定肌酐清除率、血清肌酐、尿量、尿糖和血尿素氮（BUN）水平来评估肾保护活性。对肾脏进行组织病理学检查，所有标本均检查涉及肾小管变性、肾小管坏死和肾小管间质性肾炎的形态学参数。
结果显示，给予庆大霉素（GA）后，血清肌酐、尿量、尿糖和BUN水平显著升高，肌酐清除率降低。与开心果提取物共同给药显示，所有剂量的血清肌酐、尿量、尿糖和BUN水平均降低，肌酐清除率升高，但在100mg/kg剂量下观察到的变化最为显著。此外，通过肾脏组织学检查证实了GA的肾保护作用。
该研究揭示了开心果水醇提取物的肾保护作用。这些发现表明，开心果治疗可能通过降低肾脏中的氧化应激和炎症来减轻肾功能障碍和结构损伤。
