Kawai K, Senba M, Tagawa H, Suzuki K, Matsuo T, Tsuchiyama H
Department of Pathology, Nagasaki University School of Medicine, Japan.
Zentralbl Allg Pathol. 1989;135(8):743-9.
We present a rare case of a 55 year old female with an osteoclast-type giant cell tumor of the endometrium associated with leiomyoma and adenomyosis. Multinucleated giant cells and mononuclear stromal cells reacted with vimentin and alpha-1-antichymotrypsin (AACT) using the immunoperoxidase method. Epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), and keratin exhibited negative immunoreaction in these tumor cells. Our immunohistochemical results do not support the epithelial origin of an osteoclast-type giant cell tumor and mesenchymal derivation appeared more likely, suggesting histiocytic origin.
我们报告了一例罕见的55岁女性病例，其患有与平滑肌瘤和子宫腺肌病相关的子宫内膜破骨细胞型巨细胞瘤。使用免疫过氧化物酶法，多核巨细胞和单核基质细胞与波形蛋白和α-1抗糜蛋白酶（AACT）发生反应。上皮膜抗原（EMA）、癌胚抗原（CEA）和角蛋白在这些肿瘤细胞中呈阴性免疫反应。我们的免疫组化结果不支持破骨细胞型巨细胞瘤的上皮起源，间充质来源似乎更有可能，提示组织细胞起源。
