Kuroda M, Oka T, Horiuchi H, Ishida T, Machinami R, Hebisawa A
Department of Pathology, Faculty of Medicine, University of Tokyo, Japan.
Pathol Int. 1994 Feb;44(2):158-63. doi: 10.1111/j.1440-1827.1994.tb01701.x.
Tumors resembling giant cell tumor (GCT) of bone are well known to occur in other organs and many cases have been reported to date. While GCT occurring as primary lesions in the lung are extremely rare, the authors experienced such a tumor at an autopsy of a 77 year old woman and subsequently performed histological and immunohistochemical examinations. The clinical and morphologic characteristics of this case are documented, and the literature concerning this type of tumor is reviewed. The present tumor of the lung was histologically characterized by proliferation of benign-looking osteoclast-like giant cells in association with slightly atypical mononuclear cells. The tumor cells were immunohistochemically positive for histiocytic markers but negative for epithelial markers. This case appears to be the first reported benign giant cell tumor of the lung in which histiocytic differentiation of mononuclear cells was suggested by immunohistochemistry.
众所周知，骨巨细胞瘤（GCT）样肿瘤可发生于其他器官，迄今为止已有许多病例报道。虽然原发性肺GCT极为罕见，但作者在一名77岁女性的尸检中遇到了这样一例肿瘤，随后进行了组织学和免疫组化检查。记录了该病例的临床和形态学特征，并复习了有关此类肿瘤的文献。目前的肺肿瘤在组织学上的特征是出现外观良性的破骨细胞样巨细胞增生，并伴有轻度非典型单核细胞。肿瘤细胞免疫组化显示组织细胞标志物阳性，但上皮标志物阴性。该病例似乎是首例经免疫组化提示单核细胞有组织细胞分化的肺良性巨细胞瘤报道。
