Berendt R C, Shnitka T K, Wiens E, Manickavel V, Jewell L D
Arch Pathol Lab Med. 1987 Jan;111(1):43-8.
We present a case report of osteoclast-type giant cell tumor of the pancreas and review the literature concerning this rare neoplasm, the histogenesis of which is uncertain. Electron microscopic features have suggested stromal, histiocytic, and epithelial origins to different investigators. Analysis of the present case supports and epithelial origin, with positive immunocytochemical staining for carcinoembryonic antigen and for low molecular weight keratin in the mononuclear and in some osteoclastlike giant cells. These tumor cells did not stain for mesenchymal markers (lysozyme, alpha 1-antitrypsin, alpha 1-antichymotrypsin, S100 protein). Zymogen granules, desmosomes, and zonulae occludentes were identified ultrastructurally and further support an epithelial derivation.
我们报告一例胰腺破骨细胞型巨细胞瘤，并复习有关此罕见肿瘤的文献，其组织发生尚不确定。电镜特征向不同研究者提示了基质、组织细胞及上皮来源。对本病例的分析支持上皮来源，单核细胞及部分破骨样巨细胞癌胚抗原及低分子量角蛋白免疫细胞化学染色呈阳性。这些肿瘤细胞间叶标记物（溶菌酶、α1抗胰蛋白酶、α1抗糜蛋白酶、S100蛋白）染色阴性。超微结构发现酶原颗粒、桥粒及紧密连接，进一步支持上皮来源。
