Saraiva A M
Acta Med Port. 1989 Sep;Suppl 1:15S-18S.
Biguanides are useful drugs in diabetes but their indications are very precise. The danger of lactic acidosis can be avoided with the use of metformin, the less toxic of biguanides, and strict respect for contraindications. All biguanides have a similar action, through different pharmacokinetics, and besides their hypoglycemic effect, have a favourable action on blood lipids, which increases their usefulness. Haemorheological effects, recently studied in animal research, may open a new field in the employment of biguanides.
双胍类药物对糖尿病治疗很有用，但它们的适应症非常明确。使用二甲双胍（双胍类药物中毒性较小的一种）并严格遵守禁忌症，可避免乳酸性酸中毒的风险。所有双胍类药物通过不同的药代动力学发挥相似的作用，除了降血糖作用外，对血脂也有有益作用，这增加了它们的实用性。最近在动物研究中所研究的血液流变学效应，可能会为双胍类药物的应用开辟一个新领域。
