Brunotte Linda, Beer Martin, Horie Masayuki, Schwemmle Martin
Institute of Molecular Virology, University of Muenster, Germany.
Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Germany.
Curr Opin Virol. 2016 Feb;16:114-119. doi: 10.1016/j.coviro.2016.02.003. Epub 2016 Mar 3.
The identification of influenza A-like genomic sequences in bats suggests the existence of distinct lineages of chiropteran influenza viruses in South and Central America. These viruses share similarities with conventional influenza A viruses but lack the canonical receptor-binding property and neuraminidase function. The inability to isolate infectious bat influenza viruses impeded further studies, however, reverse genetic analysis provided new insights into the molecular biology of these viruses. In this review, we highlight the recent developments in the field of the newly discovered bat-derived influenza A-like viruses. We also discuss whether bats are a neglected natural reservoir of influenza viruses, the risk associated with bat influenza viruses for humans and whether these viruses originate from the pool of avian IAV or vice versa.
在蝙蝠中鉴定出甲型流感样基因组序列，这表明在南美洲和中美洲存在不同谱系的翼手目流感病毒。这些病毒与传统甲型流感病毒有相似之处，但缺乏典型的受体结合特性和神经氨酸酶功能。无法分离出具有传染性的蝙蝠流感病毒阻碍了进一步研究，然而，反向遗传学分析为这些病毒的分子生物学提供了新的见解。在这篇综述中，我们重点介绍了新发现的蝙蝠源甲型流感样病毒领域的最新进展。我们还讨论了蝙蝠是否是被忽视的流感病毒天然宿主、蝙蝠流感病毒对人类的相关风险，以及这些病毒是否源自禽流感病毒库，或者反之亦然。
