Carlos A G
Acta Med Port. 1989 Nov;Suppl 2:S34-8.
The present concepts on histamine releasing factors are discussed, their cellular origins, their effect on the target cells and its importance in asthma immunopathology. Personal results on the production of HRF by alveolar macrophages stimulated by allergen and its action on non atopic basophils are presented. Alveolar macrophages from atopic asthmatics release HRF in presence of allergen. Macrophage from non atopic do not. HRF has been tested in a Human Basophil Degranulation Test (HBDT) preparation, a significant degranulation induced by HRF from atopic patient being only observed when atopic basophils are used in HBDT. These results confirm that allergen could induce HRF production from alveolar macrophages and that this HRF could degranulate basophils in atopic and induce mediators release.
本文讨论了目前关于组胺释放因子的概念，包括它们的细胞来源、对靶细胞的作用及其在哮喘免疫病理学中的重要性。文中展示了关于变应原刺激肺泡巨噬细胞产生组胺释放因子及其对非特应性嗜碱性粒细胞作用的个人研究结果。特应性哮喘患者的肺泡巨噬细胞在有变应原存在时会释放组胺释放因子。非特应性患者的巨噬细胞则不会。组胺释放因子已在人类嗜碱性粒细胞脱颗粒试验（HBDT）制剂中进行了测试，只有当在HBDT中使用特应性嗜碱性粒细胞时，才观察到特应性患者的组胺释放因子诱导显著的脱颗粒现象。这些结果证实，变应原可诱导肺泡巨噬细胞产生组胺释放因子，且该组胺释放因子可使特应性患者的嗜碱性粒细胞脱颗粒并诱导介质释放。
