Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
Angew Chem Int Ed Engl. 2016 Apr 4;55(15):4748-52. doi: 10.1002/anie.201511683. Epub 2016 Mar 7.
Reported herein is that the use of catalytic quantities of hypervalent iodine reagents (phenyliodine diacetate or Dess-Martin periodinane) allows the rapid and stereoselective formation of cyclobutanes under very mild reaction conditions. The presence of a fluorinated solvent is essential for the success of these reactions which form unsymmetrical tri- and tetrasubstituted cyclobutanes through a heterodimerization process involving two different alkenes.
本文报道了在催化量高价碘试剂（苯碘二乙酸或戴斯-马丁过碘烷）的作用下，在非常温和的反应条件下，可以快速、立体选择性地形成环丁烷。氟代溶剂的存在对于这些反应的成功是至关重要的，这些反应通过涉及两种不同烯烃的杂二聚化过程形成不对称的三取代和四取代环丁烷。
