Maruf Fatai Adesina, Akinpelu Aderonke Omobonike, Salako Babatunde Lawal, Akinyemi Joshua Odunayo
Department of Medical Rehabilitation, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria.
Department of Physiotherapy, Faculty of Clinical Sciences, University of Ibadan, Ibadan, Oyo State, Nigeria.
J Am Soc Hypertens. 2016 Apr;10(4):336-45. doi: 10.1016/j.jash.2016.02.002. Epub 2016 Feb 12.
There is a dearth of reports on possible additive blood pressure (BP)-reducing effect of aerobic exercise on antihypertensive drug in humans. This study investigated the additive BP-reducing effect of aerobic exercise on BP in individuals with uncontrolled hypertension. In this 12-week double-blind study, 120 new-diagnosed individuals with mild-to-moderate hypertension were randomized to receive coamilozide + 5/10 mg of amlodipine + aerobic dance or coamilozide + 5/10 mg of amlodipine alone. Forty-five and 43 participants in exercise and control groups, respectively, completed the 12-week intervention. Addition of aerobic exercise to antihypertensive drug therapy significantly reduced systolic BP (7.1 mm Hg [95% confidence interval: 5.0, 9.3]; P < .001) and diastolic BP (1.7 mm Hg [95% confidence interval: 0.4, 3.0]; P = .009) at 12 weeks. BP control rate differed significantly between exercise (53.9%) and control (35.3%) groups, P < .001. Postintervention, proportion of participants in exercise group who had their number of antihypertensive drug reduced to one (20.3%) differed from that in control group (11.1%); (χ(2) = 11.0; P = .001). Combination of aerobic dance and antihypertensive drugs reduces number of antihypertensive drugs needed to achieve BP control and enhances BP control in individuals with hypertension on two antihypertensive drugs.
关于有氧运动对人类降压药物可能存在的附加降压作用，相关报道较为匮乏。本研究调查了有氧运动对血压未得到控制的高血压患者的附加降压作用。在这项为期12周的双盲研究中，120名新诊断的轻至中度高血压患者被随机分为两组，一组接受复方阿米洛利+5/10毫克氨氯地平+有氧舞蹈训练，另一组仅接受复方阿米洛利+5/10毫克氨氯地平。运动组和对照组分别有45名和43名参与者完成了为期12周的干预。在降压药物治疗基础上加用有氧运动，在12周时显著降低了收缩压（7.1毫米汞柱[95%置信区间：5.0, 9.3]；P <.001）和舒张压（1.7毫米汞柱[95%置信区间：0.4, 3.0]；P =.009）。运动组（53.9%）和对照组（35.3%）的血压控制率差异显著，P <.001。干预后，运动组中降压药物数量减至一种的参与者比例（20.3%）与对照组（11.1%）不同；（χ(2)=11.0；P =.001）。有氧舞蹈与降压药物联合使用可减少实现血压控制所需的降压药物数量，并提高正在服用两种降压药物的高血压患者的血压控制水平。
