Jabbarzadeh Ganjeh Bahareh, Zeraattalab-Motlagh Sheida, Jayedi Ahmad, Daneshvar Mojtaba, Gohari Zahra, Norouziasl Reyhane, Ghaemi Shadi, Selk-Ghaffari Maryam, Moghadam Navid, Kordi Ramin, Shab-Bidar Sakineh
Department of Community Nutrition, Tehran University of Medical Sciences, Tehran, Iran.
Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Hypertens Res. 2024 Feb;47(2):385-398. doi: 10.1038/s41440-023-01467-9. Epub 2023 Oct 23.
We aimed to evaluate the dose-dependent effects of aerobic exercise on systolic (SBP) and diastolic blood pressure (DBP) and haemodynamic factors in adults with hypertension. PubMed, Scopus, and Web of Science were searched to April 2022 for randomized trials of aerobic exercise in adults with hypertension. We conducted a random-effects meta-analysis to estimate mean differences (MDs) and 95%CIs for each 30 min/week increase in aerobic exercise. The certainty of evidence was rated using the GRADE approach. The analysis of 34 trials with 1787 participants indicated that each 30 min/week aerobic exercise reduced SBP by 1.78 mmHg (95%CI: -2.22 to -1.33; n = 34, GRADE=low), DBP by 1.23 mmHg (95%CI: -1.53 to -0.93; n = 34, GRADE=moderate), resting heart rate (MD = -1.08 bpm, 95%CI: -1.46 to -0.71; n = 23, GRADE=low), and mean arterial pressure (MD = -1.37 mmHg, 95%CI: -1.80 to -0.93; n = 9, GRADE = low). A nonlinear dose-dependent decrement was seen on SBP and DBP, with the greatest decrement at 150 min/week (MD = -7.23 mmHg, 95%CI: -9.08 to -5.39 for SBP and -5.58 mmHg, 95%CI: -6.90 to -4.27 for DBP). Aerobic exercise can lead to a large and clinically important reduction in blood pressure in a dose-dependent manner, with the greatest reduction at 150 min/week. The dose-dependent effects of aerobic exercise on systolic and diastolic blood pressure and haemodynamic factors in adults with hypertension.
我们旨在评估有氧运动对高血压成年人收缩压（SBP）、舒张压（DBP）和血流动力学因素的剂量依赖性影响。检索了PubMed、Scopus和Web of Science截至2022年4月关于高血压成年人有氧运动的随机试验。我们进行了随机效应荟萃分析，以估计有氧运动每增加30分钟/周的平均差异（MDs）和95%置信区间（CIs）。使用GRADE方法对证据的确定性进行评级。对34项试验（1787名参与者）的分析表明，有氧运动每增加30分钟/周，SBP降低1.78 mmHg（95%CI：-2.22至-1.33；n = 34，GRADE = 低），DBP降低1.23 mmHg（95%CI：-1.53至-0.93；n = 34，GRADE = 中等），静息心率（MD = -1.08次/分钟，95%CI：-1.46至-0.71；n = 23，GRADE = 低），平均动脉压（MD = -1.37 mmHg，95%CI：-1.80至-0.93；n = 9，GRADE = 低）。在SBP和DBP上观察到非线性剂量依赖性降低，在150分钟/周时降低最大（SBP的MD = -7.23 mmHg，95%CI：-9.08至-5.39；DBP的MD = -5.58 mmHg，95%CI：-6.90至-4.27）。有氧运动可导致血压以剂量依赖性方式大幅且具有临床意义地降低，在150分钟/周时降低最大。有氧运动对高血压成年人收缩压和舒张压以及血流动力学因素的剂量依赖性影响。
