Das Chandrani, Ghosh Tarini Shankar, Mande Sharmila S
Bio-Sciences R and D Division, TCS Innovation Labs, Tata Research Development and Design Centre, Tata Consultancy Service Ltd., Pune 411 013, India.
J Biosci. 2016 Mar;41(1):133-43. doi: 10.1007/s12038-016-9599-8.
Type VII Secretion System (T7SS) is one of the factors involved in virulence of Mycobacterium tuberculosis H37Rv. Numerous research efforts have been made in the last decade towards characterizing the components of this secretion system. An extensive genome-wide analysis through compilation of isolated information is required to obtain a global view of diverse characteristics and pathogenicity-related aspects of this machinery. The present study suggests that differences in structural components (of T7SS) between Actinobacteria and Firmicutes, observed earlier in a few organisms, is indeed a global trend. A few hitherto uncharacterized T7SS-like clusters have been identified in the pathogenic bacteria Enterococcus faecalis, Saccharomonospora viridis, Streptococcus equi, Streptococcus gordonii and Streptococcus sanguinis. Experimental verification of these clusters can shed lights on their role in bacterial pathogenesis. Similarly, verification of the identified variants of T7SS clusters consisting additional membrane components may help in unraveling new mechanism of protein translocation through T7SS. A database of various components of T7SS has been developed to facilitate easy access and interpretation of T7SS related data.
VII型分泌系统（T7SS）是结核分枝杆菌H37Rv毒力相关因素之一。在过去十年中，人们为表征该分泌系统的组成成分付出了诸多研究努力。需要通过整合孤立信息进行广泛的全基因组分析，以全面了解该机制的多样特征及与致病性相关的方面。本研究表明，先前在少数生物体中观察到的放线菌门和厚壁菌门之间（T7SS）结构成分的差异确实是一种普遍趋势。在病原菌粪肠球菌、绿色糖单孢菌、马链球菌、戈登链球菌和血链球菌中已鉴定出一些此前未被表征的类似T7SS的基因簇。对这些基因簇进行实验验证可揭示它们在细菌致病过程中的作用。同样，对已鉴定出的包含额外膜成分的T7SS基因簇变体进行验证，可能有助于阐明蛋白质通过T7SS转运的新机制。已建立了一个T7SS各种成分的数据库，以方便获取和解读与T7SS相关的数据。
