Cavallin-Ståhl E, Landberg T, Ottow Z, Mitelman F
Scand J Haematol. 1977 Sep;19(3):273-80. doi: 10.1111/j.1600-0609.1977.tb02106.x.
Three patients developing acute myeloid leukaemia after treatment for Hodgkin's disease are reported. They appeared among 153 patients treated since 1971. All three patients were treated with high-voltage radiation of large target volumes as well as multiple-drug chemotherapy. In two of the patients chromosomal analyses of the leukaemic bone marrow cells were performed by modern banding technique. Chromosome abnormalities were found in both patients. The value of cytogenetic analysis with the new staining techniques for elucidating the mechanism of leukaemogenesis in Hodgkin's disease is discussed.
报告了3例霍奇金病治疗后发生急性髓细胞白血病的患者。他们出现在自1971年以来接受治疗的153例患者中。所有3例患者均接受了大靶区的高电压放疗以及多药化疗。其中2例患者采用现代显带技术对白血病骨髓细胞进行了染色体分析。在这2例患者中均发现了染色体异常。讨论了采用新染色技术进行细胞遗传学分析对阐明霍奇金病白血病发生机制的价值。
