通过乌吉四中心三组分反应高效合成2,5-二酮哌嗪衍生物。
An efficient synthesis of 2,5-diketopiperazine derivatives by the Ugi four-center three-component reaction.
作者信息
Cho Sangwon, Keum Gyochang, Kang Soon Bang, Han So-Yeop, Kim Youseung
机构信息
Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul 130-650, Korea.
出版信息
Mol Divers. 2003;6(3-4):283-6. doi: 10.1023/b:modi.0000006812.16141.b5.
Abstract
A facile synthetic approach to 2,5-diketopiperazines 4 by the Ugi four-center three-component reaction using commercially available dipeptides as a bifunctional component, aldehydes, and isocyanides was described.
摘要
描述了一种通过乌吉四中心三组分反应，以市售二肽作为双功能组分、醛和异腈来简便合成2,5-二酮哌嗪4的方法。
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