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通过乌吉四中心三组分反应高效合成2,5-二酮哌嗪衍生物。

An efficient synthesis of 2,5-diketopiperazine derivatives by the Ugi four-center three-component reaction.

作者信息

Cho Sangwon, Keum Gyochang, Kang Soon Bang, Han So-Yeop, Kim Youseung

机构信息

Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul 130-650, Korea.

出版信息

Mol Divers. 2003;6(3-4):283-6. doi: 10.1023/b:modi.0000006812.16141.b5.

DOI:10.1023/b:modi.0000006812.16141.b5
PMID:15068092
Abstract

A facile synthetic approach to 2,5-diketopiperazines 4 by the Ugi four-center three-component reaction using commercially available dipeptides as a bifunctional component, aldehydes, and isocyanides was described.

摘要

描述了一种通过乌吉四中心三组分反应,以市售二肽作为双功能组分、醛和异腈来简便合成2,5-二酮哌嗪4的方法。

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