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益髓生血颗粒对轻、中、重度贫血地中海贫血患者的临床疗效及机制

Clinical Effect and Mechanism of Yisui Shengxue Granules in Thalassemia Patients with Mild, Moderate, or Severe Anemia.

作者信息

Cheng Yan-Ling, Zhang Xin-Hua, Sun Yu-Wen, Wang Wen-Juan, Fang Su-Ping, Wu Zhi-Kui

机构信息

Laboratory of Molecular Biology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

Department of Hematology, 303rd Hospital of PLA, Nanning 530021, China.

出版信息

Evid Based Complement Alternat Med. 2016;2016:1713897. doi: 10.1155/2016/1713897. Epub 2016 Feb 2.

DOI:10.1155/2016/1713897
PMID:26949404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4754483/
Abstract

Yisui Shengxue granules, which is a Chinese traditional medicine, can increase hemoglobin, red blood cells, and Ret of thalassemia patients with mild, moderate, and severe anemia and thus relieve clinical anemia symptoms. Studies on mechanism found that Yisui Shengxue granules can increase the proliferation ability of hematopoietic stem cells. Emodin promoted colony forming of hematopoietic stem cells. Yisui Shengxue granules can increase the activity of GSH-PX in bone marrow blood and decreased the severity of inclusion bodies on the cytomembrane of RBCs. YSSXG attenuated anemia symptoms in patients with thalassemia mostly by increasing the proliferation of hematopoietic stem cells and decreasing the hemolysis of RBCs.

摘要

益髓生血颗粒是一种中药，可增加轻度、中度和重度贫血的地中海贫血患者的血红蛋白、红细胞和网织红细胞，从而缓解临床贫血症状。机制研究发现，益髓生血颗粒可提高造血干细胞的增殖能力。大黄素促进造血干细胞集落形成。益髓生血颗粒可提高骨髓血中谷胱甘肽过氧化物酶（GSH-PX）的活性，并降低红细胞细胞膜上包涵体的严重程度。益髓生血颗粒主要通过增加造血干细胞的增殖和减少红细胞的溶血来减轻地中海贫血患者的贫血症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95d5/4754483/eb5156a6d3e1/ECAM2016-1713897.011.jpg
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本文引用的文献

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Recent trends in the gene therapy of β-thalassemia.β-地中海贫血基因治疗的最新趋势
J Blood Med. 2015 Feb 19;6:69-85. doi: 10.2147/JBM.S46256. eCollection 2015.
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Thalassaemia is a tropical disease.地中海贫血是一种热带疾病。
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中药疗法对台湾遗传性溶血性贫血患者全因死亡、糖尿病相关死亡和心血管疾病相关死亡风险的影响。
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[Clinical observation of Yisui Shengxue Granule in treating 25 patients with hemoglobin H disease].益髓生血颗粒治疗25例血红蛋白H病的临床观察
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