Faryadian Sara, Khosravi Afra
Physiology Department, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Immunology Department, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Iran J Basic Med Sci. 2015 Nov;18(11):1086-92.
There is much evidence indicating that depression is influenced by the levels of neurotransmitters such as dopamine, GABA and adrenaline. The current study we designed to investigate the effect of exposure of pregnant rats to different colors on neurotransmitters level, as indicators of mood disorders in off springs.
Five groups of pregnant female Wistar rats (eight rats in each group) were enrolled in this study. Dopamine, adrenaline and GABA concentration in sera of rats were measured using ELISA.
The colors black and red elevated the GABA levels in serum and CSF while the colors green and blue decreased the GABA levels. The colors black and red also decreased the sera and CSF levels of dopamine compared to the control group. The concentration of adrenaline was increased following exposure to the colors black, red and blue but decreased only following color green exposure. These results showed serious changes in neurotransmitter levels due to exposure to different colors which can be translated as mood and behavior changes.
It can be concluded that exposure during pregnancy can lead to postpartum behavioral changes even at adulthood and such changes can be made by colors.
有大量证据表明，抑郁症受多巴胺、γ-氨基丁酸（GABA）和肾上腺素等神经递质水平的影响。我们设计了本研究，旨在调查怀孕大鼠暴露于不同颜色对神经递质水平的影响，以此作为后代情绪障碍的指标。
本研究纳入了五组怀孕的雌性Wistar大鼠（每组8只大鼠）。采用酶联免疫吸附测定法（ELISA）测量大鼠血清中的多巴胺、肾上腺素和GABA浓度。
黑色和红色使血清和脑脊液中的GABA水平升高，而绿色和蓝色则使GABA水平降低。与对照组相比，黑色和红色还降低了血清和脑脊液中的多巴胺水平。暴露于黑色、红色和蓝色后，肾上腺素浓度升高，但仅在暴露于绿色后降低。这些结果表明，暴露于不同颜色会导致神经递质水平发生严重变化，这可能转化为情绪和行为的改变。
可以得出结论，孕期暴露甚至在成年期也会导致产后行为变化，而且这种变化可能由颜色引起。
