Rubin Beatrix P, Brockes Jeremy, Galliot Brigitte, Grossniklaus Ueli, Lobo Daniel, Mainardi Marco, Mirouze Marie, Prochiantz Alain, Steger Angelika
Collegium Helveticum, University of Zurich and ETH Zurich, Zurich, 8092, Switzerland.
Department of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK.
F1000Res. 2015 Nov 18;4:1288. doi: 10.12688/f1000research.7315.1. eCollection 2015.
In recent decades, a profound conceptual transformation has occurred comprising different areas of biological research, leading to a novel understanding of life processes as much more dynamic and changeable. Discoveries in plants and animals, as well as novel experimental approaches, have prompted the research community to reconsider established concepts and paradigms. This development was taken as an incentive to organise a workshop in May 2014 at the Academia Nazionale dei Lincei in Rome. There, experts on epigenetics, regeneration, neuroplasticity, and computational biology, using different animal and plant models, presented their insights on important aspects of a dynamic architecture of life, which comprises all organisational levels of the organism. Their work demonstrates that a dynamic nature of life persists during the entire existence of the organism and permits animals and plants not only to fine-tune their response to particular environmental demands during development, but underlies their continuous capacity to do so. Here, a synthesis of the different findings and their relevance for biological thinking is presented.
近几十年来，生物学研究的不同领域发生了深刻的概念转变，使人们对生命过程有了全新的认识，即生命过程更加动态多变。动植物领域的发现以及新颖的实验方法促使研究界重新审视既定的概念和范式。这一发展态势成为了2014年5月在罗马的意大利国家科学院组织一次研讨会的契机。在此次研讨会上，表观遗传学、再生、神经可塑性和计算生物学领域的专家们运用不同的动植物模型，就生命动态结构的重要方面发表了见解，生命的动态结构涵盖了生物体的所有组织层次。他们的研究表明，生命的动态本质在生物体的整个生存过程中持续存在，不仅使动植物在发育过程中能够微调其对特定环境需求的反应，而且构成了它们持续具备这种能力的基础。在此，本文对不同的研究发现及其与生物学思维的相关性进行了综合阐述。
