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酒精性酮症酸中毒:一例病例报告及文献综述

Alcoholic ketoacidosis: a case report and review of the literature.

作者信息

Noor Nurulamin M, Basavaraju Krishna, Sharpstone Dan

机构信息

Department of Medicine , University of Cambridge , Cambridge , UK.

Department of Gastroenterology , West Suffolk Hospital , Bury St Edmunds , UK.

出版信息

Oxf Med Case Reports. 2016 Mar 3;2016(3):31-3. doi: 10.1093/omcr/omw006. eCollection 2016 Mar.

Abstract

Alcoholic ketoacidosis (AKA) is a cause of severe metabolic acidosis usually occurring in malnourished patients with a history of recent alcoholic binge, often on a background of alcohol dependency. AKA can be fatal due to associated electrolyte abnormalities and subsequent development of cardiac arrhythmias. This is a diagnosis that is often delayed or missed, in patients who present with a severe lactic and ketoacidosis. Here we report the case of a 64-year-old female who presented with generalized abdominal pain, nausea and shortness of breath. Blood gas analysis showed significant acidaemia with a pH of 7.10, bicarbonate of 2.9 mmol/l, and lactate of 11.7 mmol/l. Serum ketones were raised at 5.5 mmol/l. The diagnosis of AKA was suspected, and subsequent aggressive fluid resuscitation, management and monitoring were instituted. Given the early recognition of AKA and appropriate multidisciplinary team management, our patient had a good outcome and was discharged home without any complication.

摘要

酒精性酮症酸中毒(AKA)是严重代谢性酸中毒的一个病因,通常发生在近期有酗酒史的营养不良患者中,且往往存在酒精依赖背景。由于相关的电解质异常及随后发生的心律失常,AKA可能会致命。对于出现严重乳酸和酮症酸中毒的患者,这一诊断常常会延迟或被漏诊。在此,我们报告一例64岁女性患者,她出现了全腹痛、恶心及呼吸急促症状。血气分析显示存在明显的酸血症,pH值为7.10,碳酸氢盐为2.9 mmol/L,乳酸为11.7 mmol/L。血清酮体升高至5.5 mmol/L。怀疑为AKA诊断,随后进行了积极的液体复苏、处理及监测。鉴于对AKA的早期识别及多学科团队的恰当管理,我们的患者预后良好,无任何并发症出院回家。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a222/4776050/5bfa308d1d24/omw00601.jpg

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