E1040对耐亚胺培南铜绿假单胞菌菌株的体外活性。
In vitro activity of E1040 against imipenem-resistant Pseudomonas aeruginosa strains.
作者信息
Watanabe M, Inoue E, Katsu K, Iyobe S, Mitsuhashi S
机构信息
Episome Institute, Seta-gun, Japan.
出版信息
Antimicrob Agents Chemother. 1992 Mar;36(3):684-6. doi: 10.1128/AAC.36.3.684.
Abstract
E1040 showed the most potent activity (MIC for 90% of strains, 6.25 micrograms/ml) among beta-lactams tested against 70 strains of imipenem-resistant Pseudomonas aeruginosa. Two strains showed high-level resistance to E1040; one strain produced a type II oxyiminocephalosporin-hydrolyzing beta-lactamase (group 3), and the other produced an enzyme similar to a type II penicillinase (OXA-1). Both beta-lactamases contributed to resistance to E1040.
摘要
在针对70株耐亚胺培南铜绿假单胞菌进行测试的β-内酰胺类药物中，E1040显示出最强的活性（对90%菌株的最低抑菌浓度为6.25微克/毫升）。有两株菌对E1040表现出高水平耐药；一株产生II型氧亚氨基头孢菌素水解β-内酰胺酶（3组），另一株产生一种类似于II型青霉素酶（OXA-1）的酶。这两种β-内酰胺酶都导致了对E1040的耐药。
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