与质粒介导的SHV型CAZ-5β-内酰胺酶对头孢他啶水解活性相关的结构特征
Structural features related to hydrolytic activity against ceftazidime of plasmid-mediated SHV-type CAZ-5 beta-lactamase.
作者信息
Péduzzi J, Barthélémy M, Tiwari K, Mattioni D, Labia R
机构信息
Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique Unité de Recherche Associée, Paris, France.
出版信息
Antimicrob Agents Chemother. 1989 Dec;33(12):2160-3. doi: 10.1128/AAC.33.12.2160.
Abstract
Tryptic peptides of the novel ceftazidimase CAZ-5 were sequenced by manual Edman degradation and aligned according to strong homology (more than 98%) with SHV-1 and SHV-2 beta-lactamase sequences. CAZ-5 differed from SHV-1 by five amino acid substitutions. Unusually high activity of CAZ-5 towards ceftazidime was imputed to substitution of a Lys for a Glu at position 214 of the mature protein.
摘要
新型头孢他啶酶CAZ-5的胰蛋白酶肽段通过手动埃德曼降解法进行测序，并根据与SHV-1和SHV-2β-内酰胺酶序列的高度同源性（超过98%）进行比对。CAZ-5与SHV-1有五个氨基酸取代差异。CAZ-5对头孢他啶的异常高活性归因于成熟蛋白214位的赖氨酸被谷氨酸取代。
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本文引用的文献
1
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Rev Infect Dis. 1983 Jul-Aug;5(4):639-48. doi: 10.1093/clinids/5.4.639.
2
Chromosomal beta-lactamases of Enterobacter cloacae are responsible for resistance to third-generation cephalosporins.阴沟肠杆菌的染色体β-内酰胺酶是导致对第三代头孢菌素耐药的原因。
Antimicrob Agents Chemother. 1983 Jun;23(6):918-25. doi: 10.1128/AAC.23.6.918.
3
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Infection. 1983 Nov-Dec;11(6):315-7. doi: 10.1007/BF01641355.
4
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Philos Trans R Soc Lond B Biol Sci. 1980 May 16;289(1036):321-31. doi: 10.1098/rstb.1980.0049.
5
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Antimicrob Agents Chemother. 1985 Aug;28(2):302-7. doi: 10.1128/AAC.28.2.302.
6
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7
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Ann Inst Pasteur Microbiol (1985). 1986 Jul-Aug;137B(1):19-27. doi: 10.1016/s0769-2609(86)80090-4.
8
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J Antimicrob Chemother. 1987 Sep;20(3):323-34. doi: 10.1093/jac/20.3.323.
9
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10
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