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1
Structural features related to hydrolytic activity against ceftazidime of plasmid-mediated SHV-type CAZ-5 beta-lactamase.与质粒介导的SHV型CAZ-5β-内酰胺酶对头孢他啶水解活性相关的结构特征
Antimicrob Agents Chemother. 1989 Dec;33(12):2160-3. doi: 10.1128/AAC.33.12.2160.
2
The kinetics of CAZ-5, a novel SHV-related plasmid-mediated beta-lactamase with enhanced hydrolytic activity against ceftazidime.CAZ-5的动力学研究，CAZ-5是一种新型的与SHV相关的质粒介导的β-内酰胺酶，对头孢他啶具有增强的水解活性。
Drugs Exp Clin Res. 1989;15(11-12):535-40.
3
A new SHV-derived extended-spectrum beta-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the -loop.一种新的源自SHV的超广谱β-内酰胺酶（SHV-24），它通过β-环中的单个氨基酸取代（D179G）水解头孢他啶。
Antimicrob Agents Chemother. 2000 Jun;44(6):1725-7. doi: 10.1128/AAC.44.6.1725-1727.2000.
4
Single amino acid substitution between SHV-1 beta-lactamase and cefotaxime-hydrolyzing SHV-2 enzyme.SHV-1β-内酰胺酶与水解头孢噻肟的SHV-2酶之间的单氨基酸取代。
FEBS Lett. 1988 Apr 11;231(1):217-20. doi: 10.1016/0014-5793(88)80734-8.
5
OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs.OXA-48 介导的头孢他啶-阿维巴坦耐药与进化权衡有关。
mSphere. 2019 Mar 27;4(2):e00024-19. doi: 10.1128/mSphere.00024-19.
6
Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis.CTX-M 家族中底物特异性的定义：天冬氨酸 240 在头孢他啶水解中的作用。
Antimicrob Agents Chemother. 2018 May 25;62(6). doi: 10.1128/AAC.00116-18. Print 2018 Jun.
7
Role of Ser-238 and Lys-240 in the hydrolysis of third-generation cephalosporins by SHV-type beta-lactamases probed by site-directed mutagenesis and three-dimensional modeling.通过定点诱变和三维建模探究Ser-238和Lys-240在SHV型β-内酰胺酶水解第三代头孢菌素中的作用
J Biol Chem. 1993 Feb 15;268(5):3690-7.
8
Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.碳青霉烯酶 2（KPC-2），在 Ambler 位置 Asp179 的取代以及对头孢他啶-阿维巴坦的耐药性：β-内酰胺酶蛋白质工程产生独特的抗生素耐药表型。
mBio. 2017 Oct 31;8(5):e00528-17. doi: 10.1128/mBio.00528-17.
9
Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime.对TEM-1β-内酰胺酶237-240位氨基酸残基进行取代选择及特性鉴定，该取代改变了对氨曲南和头孢他啶的底物特异性。
J Biol Chem. 1996 Sep 13;271(37):22538-45. doi: 10.1074/jbc.271.37.22538.
10
Plasmid-mediated beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli resistant to ceftazidime.肺炎克雷伯菌和大肠埃希菌临床分离株中对头孢他啶耐药的质粒介导β-内酰胺酶
Antimicrob Agents Chemother. 1989 May;33(5):757-61. doi: 10.1128/AAC.33.5.757.

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1
A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous.超广谱β-内酰胺酶综述：被忽视却无处不在
Front Microbiol. 2016 Sep 5;7:1374. doi: 10.3389/fmicb.2016.01374. eCollection 2016.
2
Multidrug-resistant phenotype and isolation of a novel SHV- beta-Lactamase variant in a clinical isolate of Enterobacter cloacae.阴沟肠杆菌临床分离株中的多重耐药表型及一种新型SHV-β-内酰胺酶变体的分离
J Biomed Sci. 2015 Apr 11;22(1):27. doi: 10.1186/s12929-015-0131-5.
3
Rapid functional definition of extended spectrum β-lactamase activity in bacterial cultures via competitive inhibition of fluorescent substrate cleavage.通过荧光底物裂解的竞争性抑制作用，快速定义细菌培养物中扩展谱β-内酰胺酶活性。
Photochem Photobiol. 2010 Nov-Dec;86(6):1267-71. doi: 10.1111/j.1751-1097.2010.00801.x. Epub 2010 Sep 20.
4
Beta-lactamase nomenclature.β-内酰胺酶命名法。
Antimicrob Agents Chemother. 2006 Apr;50(4):1123-9. doi: 10.1128/AAC.50.4.1123-1129.2006.
5
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.社区及私立医疗保健中心产超广谱β-内酰胺酶的肠杆菌科细菌
Antimicrob Agents Chemother. 2003 Nov;47(11):3506-14. doi: 10.1128/AAC.47.11.3506-3514.2003.
6
A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil.在巴西分离出的粘质沙雷氏菌中发现的一种新型A类超广谱β-内酰胺酶（BES-1）。
Antimicrob Agents Chemother. 2000 Nov;44(11):3061-8. doi: 10.1128/AAC.44.11.3061-3068.2000.
7
Contribution of natural amino acid substitutions in SHV extended-spectrum beta-lactamases to resistance against various beta-lactams.SHV超广谱β-内酰胺酶中天然氨基酸取代对多种β-内酰胺耐药性的贡献。
Antimicrob Agents Chemother. 2000 Oct;44(10):2759-63. doi: 10.1128/AAC.44.10.2759-2763.2000.
8
Characterization of the extended-spectrum beta-lactamase reference strain, Klebsiella pneumoniae K6 (ATCC 700603), which produces the novel enzyme SHV-18.产新型酶SHV-18的超广谱β-内酰胺酶参考菌株肺炎克雷伯菌K6（ATCC 700603）的特性分析
Antimicrob Agents Chemother. 2000 Sep;44(9):2382-8. doi: 10.1128/AAC.44.9.2382-2388.2000.
9
Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.对于bla(SHV)基因的核苷酸测序，自动热循环法优于传统方法。
Antimicrob Agents Chemother. 1999 Dec;43(12):2960-3. doi: 10.1128/AAC.43.12.2960.
10
A237T as a modulating mutation in naturally occurring extended-spectrum TEM-type beta-lactamases.A237T作为天然存在的超广谱TEM型β-内酰胺酶中的一种调节性突变。
Antimicrob Agents Chemother. 1998 May;42(5):1042-4. doi: 10.1128/AAC.42.5.1042.

本文引用的文献

1
Emergence of resistance during therapy with the newer beta-lactam antibiotics: role of inducible beta-lactamases and implications for the future.新型β-内酰胺类抗生素治疗期间耐药性的出现：诱导性β-内酰胺酶的作用及对未来的影响。
Rev Infect Dis. 1983 Jul-Aug;5(4):639-48. doi: 10.1093/clinids/5.4.639.
2
Chromosomal beta-lactamases of Enterobacter cloacae are responsible for resistance to third-generation cephalosporins.阴沟肠杆菌的染色体β-内酰胺酶是导致对第三代头孢菌素耐药的原因。
Antimicrob Agents Chemother. 1983 Jun;23(6):918-25. doi: 10.1128/AAC.23.6.918.
3
Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens.肺炎克雷伯菌和粘质沙雷氏菌临床分离株对头孢噻肟、头孢西丁、头孢孟多和头孢呋辛的可转移性耐药性。
Infection. 1983 Nov-Dec;11(6):315-7. doi: 10.1007/BF01641355.
4
The structure of beta-lactamases.β-内酰胺酶的结构
Philos Trans R Soc Lond B Biol Sci. 1980 May 16;289(1036):321-31. doi: 10.1098/rstb.1980.0049.
5
Evolution of plasmid-coded resistance to broad-spectrum cephalosporins.质粒编码的对广谱头孢菌素耐药性的演变。
Antimicrob Agents Chemother. 1985 Aug;28(2):302-7. doi: 10.1128/AAC.28.2.302.
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Beta-lactam antibiotics and selection of resistance: speculation on the evolution of R-plasmids.
J Antimicrob Chemother. 1986 Oct;18 Suppl C:113-21. doi: 10.1093/jac/18.supplement_c.113.
7
Purification and biochemical properties of Pitton's type 2 beta-lactamase (SHV-1).皮顿2型β-内酰胺酶（SHV-1）的纯化及生化特性
Ann Inst Pasteur Microbiol (1985). 1986 Jul-Aug;137B(1):19-27. doi: 10.1016/s0769-2609(86)80090-4.
8
Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase.肺炎克雷伯菌临床分离株对第三代头孢菌素的可转移耐药性：新型β-内酰胺酶CTX-1的鉴定
J Antimicrob Chemother. 1987 Sep;20(3):323-34. doi: 10.1093/jac/20.3.323.
9
Novel R-factor borne beta-lactamase of Escherichia coli confering resistance to cephalosporins.大肠杆菌中携带的新型R因子β-内酰胺酶赋予对头孢菌素的抗性。
Infection. 1987 Jul-Aug;15(4):257-9. doi: 10.1007/BF01644127.
10
Clinical significance of beta-lactamase induction and stable derepression in gram-negative rods.革兰氏阴性杆菌中β-内酰胺酶诱导和稳定去阻遏的临床意义
Eur J Clin Microbiol. 1987 Aug;6(4):439-45. doi: 10.1007/BF02013107.

与质粒介导的SHV型CAZ-5β-内酰胺酶对头孢他啶水解活性相关的结构特征

Structural features related to hydrolytic activity against ceftazidime of plasmid-mediated SHV-type CAZ-5 beta-lactamase.

作者信息

Péduzzi J, Barthélémy M, Tiwari K, Mattioni D, Labia R

机构信息

Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique Unité de Recherche Associée, Paris, France.

出版信息

Antimicrob Agents Chemother. 1989 Dec;33(12):2160-3. doi: 10.1128/AAC.33.12.2160.

DOI:10.1128/AAC.33.12.2160
PMID:2694955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172844/
Abstract

Tryptic peptides of the novel ceftazidimase CAZ-5 were sequenced by manual Edman degradation and aligned according to strong homology (more than 98%) with SHV-1 and SHV-2 beta-lactamase sequences. CAZ-5 differed from SHV-1 by five amino acid substitutions. Unusually high activity of CAZ-5 towards ceftazidime was imputed to substitution of a Lys for a Glu at position 214 of the mature protein.

摘要

新型头孢他啶酶CAZ-5的胰蛋白酶肽段通过手动埃德曼降解法进行测序，并根据与SHV-1和SHV-2β-内酰胺酶序列的高度同源性（超过98%）进行比对。CAZ-5与SHV-1有五个氨基酸取代差异。CAZ-5对头孢他啶的异常高活性归因于成熟蛋白214位的赖氨酸被谷氨酸取代。