Kang Eun Kyoung, Jeong Hyun Sun, Moon Eun Rhan, Lee Joo Young, Lee Kun Jai
Department of Rehabilitation Medicine, Kangwon National University Hospital, Chuncheon, Korea.
Department of Rehabilitation Medicine, Seoul Bukbu Hospital, Seoul, Korea.
Ann Rehabil Med. 2016 Feb;40(1):152-61. doi: 10.5535/arm.2016.40.1.152. Epub 2016 Feb 26.
To assess the clinical usefulness of the relatively short instrument, the Korean version of the Mini-Mental State Examination (MMSE-K), for testing the association between cognition and language function in subacute post-stroke aphasia patients.
Medical charts of 111 post-stroke patients (65 men; age 69.6±10.0 years; 124.6±80.6 days post-onset) were reviewed retrospectively. All patients were assessed longitudinally for aphasia using the validated Korean version of the Western Aphasia Battery (K-WAB) and for cognition using the MMSE-K. Patients were categorized and analyzed according to 3 aphasia-severity clusters.
All subscales of the K-WAB showed significant improvement in follow-up assessments in all groups (p<0.05 or p<0.01). Only the scores of orientation, language function, and total score of MMSE-K showed significant improvement in all groups (p<0.01). The more severely impaired group showed stronger Pearson correlation coefficients between cognition and language function. Additionally, comparisons between correlation coefficients showed that the association of improvement in orientation with that of fluency and AQ% (aphasia quotient %) was significant in the more severely impaired group.
Among subacute post-stroke aphasic patients, patients with more severe aphasia showed greater impairments to cognitive function; in addition, recovery of orientation may be related to recovery of language function.
评估相对简短的工具——韩国版简易精神状态检查表(MMSE-K),在测试亚急性脑卒中后失语症患者认知与语言功能之间关联方面的临床实用性。
回顾性分析111例脑卒中后患者(65例男性;年龄69.6±10.0岁;发病后124.6±80.6天)的病历。所有患者均使用经过验证的韩国版西方失语成套测验(K-WAB)进行失语症纵向评估,并使用MMSE-K进行认知评估。根据3个失语严重程度类别对患者进行分类和分析。
K-WAB的所有分量表在所有组的随访评估中均显示出显著改善(p<0.05或p<0.01)。仅MMSE-K的定向、语言功能和总分在所有组中显示出显著改善(p<0.01)。受损越严重的组在认知与语言功能之间显示出更强的皮尔逊相关系数。此外,相关系数比较显示,在受损更严重的组中,定向改善与流畅性改善以及失语商百分比(AQ%)改善之间的关联显著。
在亚急性脑卒中后失语症患者中,失语症越严重的患者认知功能受损越严重;此外,定向恢复可能与语言功能恢复有关。