Academia Sinica , Institute of Chemistry, 128 Sect 2 Acad Road, Taipei 115, Taiwan.
State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
Org Lett. 2016 Mar 18;18(6):1234-7. doi: 10.1021/acs.orglett.5b03690. Epub 2016 Mar 7.
By employing a simple, inexpensive, and transition-metal-free oxidation system, secondary C-H bonds in a series of phthaloyl protected primary amines and amino acid derivatives were oxidized to carbonyls with good regioselectivities. This method could also be applied to oxidize tertiary C-H bonds and modify synthetic dipeptides.
采用一种简单、廉价且无过渡金属的氧化体系，一系列邻苯二甲酰基保护的伯胺和氨基酸衍生物中的仲 C-H 键可被选择性地氧化为羰基。该方法也可用于氧化叔 C-H 键和修饰合成二肽。
