无金属、高效的苄位 C-H 键有机催化胺化反应。
Metal-free, highly efficient organocatalytic amination of benzylic C-H bonds.
机构信息
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, People's Republic of China.
出版信息
Chem Commun (Camb). 2013 May 7;49(35):3700-2. doi: 10.1039/c3cc41558a. Epub 2013 Mar 27.
PMID:23536004
Abstract
A new synthetic approach toward direct C-N bond formation through sp(3) C-H activation has been developed under metal-free conditions. Both primary and secondary benzylic C-H substrates could react smoothly with various amines to give only mono-amination products with good to excellent yields.
摘要
一种新的合成方法，通过 sp(3) C-H 活化实现直接 C-N 键形成，在无金属条件下得到了发展。伯位和仲位苄基 C-H 底物都能与各种胺类化合物顺利反应，仅得到单胺化产物，产率良好至优秀。
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