芳胺的催化 C-H 胺化反应。
Catalytic C-H amination with aromatic amines.
机构信息
Department of Chemistry, Georgetown University, Box 571227, Washington, DC 20057-1227, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6488-92. doi: 10.1002/anie.201201921. Epub 2012 May 15.
PMID:22589147
Abstract
Aniline joins the club: A β-diketiminato copper(I) catalyst enables C-H amination of anilines employing low catalyst loadings to preclude oxidation to the diazene ArN=NAr. Electron-poor anilines are particularly resistant towards diazene formation and participate in the amination of strong and unactivated C-H bonds. N-alkyl anilines also take part in C-H amination.
摘要
苯胺加入俱乐部
β-二酮亚胺铜（I）催化剂能够实现苯胺的 C-H 氨化，使用低催化剂负载量来避免氧化为偶氮苯 ArN=NAr。缺电子苯胺特别不易形成偶氮苯，并且能够参与强的和未活化的 C-H 键的氨化反应。N-烷基苯胺也参与 C-H 氨化反应。
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