Keenan Kathryn E, Wilmes Lisa J, Aliu Sheye O, Newitt David C, Jones Ella F, Boss Michael A, Stupic Karl F, Russek Stephen E, Hylton Nola M
Physical Measurement Laboratory, National Institute of Standards and Technology, Boulder, Colorado, USA.
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
J Magn Reson Imaging. 2016 Sep;44(3):610-9. doi: 10.1002/jmri.25214. Epub 2016 Mar 7.
We present a breast phantom designed to enable quantitative assessment of measurements of T1 relaxation time, apparent diffusion coefficient (ADC), and other attributes of breast tissue, with long-term support from a national metrology institute.
A breast phantom was created with two independent, interchangeable units for diffusion and T1 /T2 relaxation, each with flexible outer shells. The T1 unit was filled with corn syrup solution and grapeseed oil to mimic the relaxation behavior of fibroglandular and fatty tissues, respectively. The diffusion unit contains plastic tubes filled with aqueous solutions of polyvinylpyrrolidone (PVP) to modulate the ADC. The phantom was imaged at 1.5T and 3.0T using magnetic resonance imaging (MRI) scanners and common breast coils from multiple manufacturers to assess T1 and T2 relaxation time and ADC values.
The fibroglandular mimic exhibited target T1 values on 1.5T and 3.0T clinical systems (25-75 percentile range: 1289 to 1400 msec and 1533 to 1845 msec, respectively) across all bore temperatures. PVP solutions mimicked the range of ADC values from malignant tumors to normal breast tissue (40% PVP median: 633 × 10(-6) mm(2) /s to 0% PVP median: 2231 × 10(-6) mm(2) /s) at temperatures of 17-24°C. The interchangeable phantom units allowed both the diffusion and T1 /T2 units to be tested on the left and right sides of the coil to assess any variation.
This phantom enables T1 and ADC measurements, fits in a variety of clinical breast coils, and can serve as a quality control tool to facilitate the standardization of quantitative measurements for breast MRI. J. Magn. Reson. Imaging 2016;44:610-619.
我们展示一种乳腺体模，旨在能够定量评估T1弛豫时间、表观扩散系数（ADC）以及乳腺组织的其他属性，并得到一家国家计量机构的长期支持。
制作了一种乳腺体模，它有两个独立的、可互换的用于扩散和T1/T2弛豫的单元，每个单元都有柔性外壳。T1单元填充糖浆溶液和葡萄籽油，分别模拟纤维腺组织和脂肪组织的弛豫行为。扩散单元包含装有聚乙烯吡咯烷酮（PVP）水溶液的塑料管，用于调节ADC。使用磁共振成像（MRI）扫描仪和多个制造商的通用乳腺线圈在1.5T和3.0T对该体模进行成像，以评估T1和T2弛豫时间以及ADC值。
在所有孔径温度下，纤维腺组织模拟物在1.5T和3.0T临床系统上呈现出目标T1值（25 - 75百分位数范围：分别为1289至1400毫秒和1533至1845毫秒）。在17 - 24°C温度下，PVP溶液模拟了从恶性肿瘤到正常乳腺组织的ADC值范围（40% PVP中位数：633×10⁻⁶ 平方毫米/秒至0% PVP中位数：2231×10⁻⁶ 平方毫米/秒）。可互换的体模单元允许在线圈的左侧和右侧对扩散单元和T1/T2单元进行测试，以评估任何差异。
这种体模能够进行T1和ADC测量，适用于各种临床乳腺线圈，并可作为一种质量控制工具，以促进乳腺MRI定量测量的标准化。《磁共振成像杂志》2016年；44:610 - 619。
