Shim Seong Hee, Kim Soo-Geun, Bae Jeong Hun, Yu Hyeong Gon, Song Su Jeong
a Department of Ophthalmology, Kangbuk Samsung Hospital , Sungkyunkwan University School of Medicine , Seoul , South Korea.
b Department of Occupational Environmental Medicine , Kangbuk Samsung Medical Center of Sungkyunkwan University , Seoul , South Korea.
Ophthalmic Epidemiol. 2016;23(2):80-7. doi: 10.3109/09286586.2015.1129425. Epub 2016 Mar 7.
To identify risk factors for the progression of early age-related macular degeneration (AMD) in Koreans.
This study was conducted at a health-screening center and followed a prospective cohort study design. Of 10,890 participants older than 50 years, 318 (2.92%) presented with early AMD. Among these 318 participants, we re-examined 172 participants after a mean duration of 4.4 years. Progression was defined by the Age-Related Eye Disease Study (AREDS) simplified AMD severity scale. Multivariable logistic regression was used to examine associations between AMD progression and baseline physical, demographic, behavioral, and ocular characteristics.
Of the 172 participants with early AMD who were re-examined, 34 (19.8%) had progression. Multivariable analyses revealed that current smoking (odds ratio, OR, 7.0, 95% confidence interval, CI, 1.4-34.4, adjusted for age, alcohol consumption, body mass index, BMI, blood pressure, BP, total cholesterol, and high density lipoprotein, HDL, cholesterol) and hypertension (OR 10.3, 95% CI 1.9-55.7, adjusted for age, smoking status, alcohol consumption, BMI, total cholesterol, and HDL cholesterol) were independently associated with progression of early AMD. Additionally, the presence of a central drusen lesion within one-third disc diameter of the macula (age-adjusted OR 4.8, 95% CI 1.3-17.6) and 20 or more drusen (age adjusted OR 7.8, 95% CI 2.5-24.0) were independently associated with progression of early AMD.
Current smoking, hypertension, central drusen location, and increasing number of drusen were associated with an increased risk of early AMD progression in Koreans.
确定韩国人早期年龄相关性黄斑变性（AMD）进展的危险因素。
本研究在一家健康筛查中心进行，采用前瞻性队列研究设计。在10890名50岁以上的参与者中，318人（2.92%）患有早期AMD。在这318名参与者中，我们在平均4.4年的时间后对172名参与者进行了重新检查。进展情况根据年龄相关性眼病研究（AREDS）简化的AMD严重程度量表进行定义。多变量逻辑回归用于检验AMD进展与基线身体、人口统计学、行为和眼部特征之间的关联。
在重新检查的172名早期AMD参与者中，34人（19.8%）出现了进展。多变量分析显示，当前吸烟（比值比，OR，7.0，95%置信区间，CI，1.4 - 34.4，调整了年龄、饮酒、体重指数、BMI、血压、BP、总胆固醇和高密度脂蛋白、HDL、胆固醇）和高血压（OR 10.3，95% CI 1.9 - 55.7，调整了年龄、吸烟状况、饮酒、BMI、总胆固醇和HDL胆固醇）与早期AMD的进展独立相关。此外，黄斑中心凹三分之一视盘直径范围内存在中心性玻璃膜疣病变（年龄调整后的OR 4.8，95% CI 1.3 - 17.6）和20个或更多玻璃膜疣（年龄调整后的OR 7.8，95% CI 2.5 - 24.0）与早期AMD的进展独立相关。
当前吸烟、高血压、中心性玻璃膜疣位置以及玻璃膜疣数量增加与韩国人早期AMD进展风险增加相关。
