突尼斯人群中母亲及其新生儿维生素D缺乏症的患病率。

Prevalence of vitamin D deficiency in mothers and their newborns in a Tunisian population.

作者信息

Ayadi Imene D, Nouaili Emira B H, Talbi Emna, Ghdemssi Aicha, Rached Chiraz, Bahlous Afef, Gammoudi Amel, Hamouda Sonia Ben, Bouguerra Badreddine, Bouzid Kehna, Abdelmoula Jouda, Marrakchi Zahra

机构信息

Department of Neonatology, Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia.

出版信息

Int J Gynaecol Obstet. 2016 May;133(2):192-5. doi: 10.1016/j.ijgo.2015.09.029. Epub 2016 Feb 12.

DOI:10.1016/j.ijgo.2015.09.029

PMID:26952350

Abstract

OBJECTIVE

To assess vitamin D status in mothers and their newborns and identify predictive factors of vitamin D deficiency.

METHODS

A cross-sectional study was undertaken of healthy women and their full-term newborns delivered at the Charles Nicolle Hospital, Tunis, Tunisia, between October and November 2012. Maternal and neonatal serum 25-hydroxy vitamin D (25(OH)D) concentrations were measured. Correlations were tested.

RESULTS

Overall, 87 mothers and their newborns were enrolled. No mother or neonate had an adequate vitamin D status. Mean maternal and neonatal serum 25(OH)D concentrations were 6.82±5.14ng/mL (range 3.60-23.77) and 5.92±4.15ng/mL (range 3.60-22.28), respectively. Vitamin D deficiency (serum 25(OH)D<20ng/mL) was found in 84 (97%) mothers and 85 (98%) neonates, of whom 76 (87%) and 78 (90%), respectively, had severe deficiency (serum 25(OH)D<12ng/mL). Maternal serum 25(OH)D showed a strong positive correlation with neonatal serum 25(OH)D (r=0.69, P<0.001). Maternal dietary vitamin D intake was the only factor shown to be associated with serum 25(OH)D concentrations (P<0.05).

CONCLUSION

Vitamin D deficiency is prevalent among Tunisian mothers and their neonates.

摘要

目的

评估母亲及其新生儿的维生素D状况，并确定维生素D缺乏的预测因素。

方法

于2012年10月至11月在突尼斯突尼斯市查尔斯·尼科勒医院对健康女性及其足月新生儿进行了一项横断面研究。测量了母亲和新生儿血清25-羟基维生素D（25(OH)D）浓度，并进行了相关性检验。

结果

总共纳入了87对母亲及其新生儿。没有一位母亲或新生儿的维生素D状况充足。母亲和新生儿血清25(OH)D的平均浓度分别为6.82±5.14ng/mL（范围3.60 - 23.77）和5.92±4.15ng/mL（范围3.60 - 22.28）。84位（97%）母亲和85位（98%）新生儿存在维生素D缺乏（血清25(OH)D<20ng/mL），其中分别有76位（87%）和78位（90%）存在严重缺乏（血清25(OH)D<12ng/mL）。母亲血清25(OH)D与新生儿血清25(OH)D呈强正相关（r = 0.69，P<0.001）。母亲饮食中维生素D的摄入量是唯一与血清25(OH)D浓度相关的因素（P<0.05）。