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胃溃疡的长期内镜随访的效用。相关上皮发育异常的研究

[Usefulness of long-term endoscopic follow-up of gastric ulcer. Study of related epithelial dysplasia].

作者信息

De Bernardin M, Bortolozzi E, Danieli F, Sicari U, Pinto G, Gatto F, Bragato N, Corso G F

机构信息

Presidio Ospedaliero di Noale - U.L.S.S. N. 17 - Regione Veneto, Servizio di Endoscopia Divisione Chirurgica.

出版信息

Chir Ital. 1989 Feb;41(1):10-21.

PMID:2695261
Abstract

Over the period from January 1980 to March 1988 the frequency of dysplastic abnormalities associated wits 202 apparently benign gastric ulcers was determined and their course monitored. The relevant data were then evaluated separately for the various subgroups the ulcers were divided into on the basis of their natural history. No correlation was detected between natural history of gastric ulcer, dysplasia and onset of cancer. Though all dysplastic forms (mild, moderate and severe) may regress, all three showed a possibility of progression to EGC, obviously in increasing percentages: mild dysplasia: 2.53%; moderate dysplasia: 4.76%; severe dysplasia: 14.29%. The last of these three values appears to indicate a greater risk of cancer onset than in simple gastric ulcer and thus proves a useful marker for a more thorough monitoring of such patients.

摘要

在1980年1月至1988年3月期间,对202例明显良性胃溃疡相关的发育异常频率进行了测定,并对其病程进行了监测。然后根据溃疡的自然史将其分为不同亚组,分别对相关数据进行评估。未发现胃溃疡的自然史、发育异常与癌症发生之间存在相关性。虽然所有发育异常形式(轻度、中度和重度)都可能消退,但这三种情况都显示出进展为早期胃癌的可能性,显然比例在增加:轻度发育异常:2.53%;中度发育异常:4.76%;重度发育异常:14.29%。这三个值中的最后一个似乎表明癌症发生的风险比单纯胃溃疡更大,因此证明是对这类患者进行更全面监测的有用标志物。

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