Sui Shuang Ge, Wu Ming Xiang, King Mark E, Zhang Yan, Ling Li, Xu Jian Min, Weng Xu Chu, Duan Lian, Shan Bao Ci, Li Ling Jiang
1Mental Health Institute, Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, P. R. China.
2ShenZhen People's Hospital, Guangdong 518020, P. R. China.
Acta Neuropsychiatr. 2010 Jun;22(3):118-26. doi: 10.1111/j.1601-5215.2010.00459.x.
Sui SG, Wu MX, King ME, Zhang Y, Ling L, Xu JM, Weng XC, Duan L, Shan BC, Li LJ. Abnormal grey matter in victims of rape with PTSD in Mainland China: a voxel-based morphometry study.
This study examined changes in brain grey matter in victims of rape (VoR) with and without post-traumatic stress disorder (PTSD). Previous research has focused on PTSD caused by various traumatic events, such as war and disaster, among others. Although considerable research has focused on rape-related PTSD, limited studies have been carried out in the context of Mainland China.
The study included 11 VoR with PTSD, 8 VoR without PTSD and 12 healthy comparison (HC) subjects. We used voxel-based morphometry to explore changes in brain grey-matter density (GMD) by applying statistical parametric mapping to high-resolution magnetic resonance images.
Compared with HC, VoR with PTSD showed significant GMD reductions in the bilateral medial frontal cortex, left middle frontal cortex, middle temporal gyrus and fusiform cortex and significant GMD increases in the right posterior cingulate cortex, postcentral cortex, bilateral precentral cortex and inferior parietal lobule. Compared to VoR without PTSD, VoR with PTSD showed significant GMD reductions in the right uncus, left middle temporal gyrus, and the fusiform cortex, and increases in the left precentral cortex, inferior parietal lobule and right post-central cortex.
The findings of abnormal GMD in VoR with PTSD support the hypothesis that PTSD is associated with widespread anatomical changes in the brain. The medial frontal cortex, precentral cortex, posterior cingulate cortex, post-central cortex and inferior parietal lobule may play important roles in the neuropathology of PTSD.
隋世刚、吴明霞、金美娥、张艳、凌莉、徐静敏、翁小川、段炼、单保晨、李丽君。中国大陆创伤后应激障碍（PTSD）强奸受害者的灰质异常：基于体素的形态学研究。
本研究调查了有和没有创伤后应激障碍（PTSD）的强奸受害者（VoR）的脑灰质变化。以往研究主要关注战争、灾难等各种创伤事件导致的PTSD。虽然已有大量研究聚焦于与强奸相关的PTSD，但在中国大陆背景下开展的研究有限。
本研究纳入11名患有PTSD的VoR、8名未患PTSD的VoR和12名健康对照（HC）受试者。我们通过将统计参数映射应用于高分辨率磁共振图像，采用基于体素的形态学方法来探索脑灰质密度（GMD）的变化。
与HC相比，患有PTSD的VoR在双侧内侧额叶皮质、左侧额中回、颞中回和梭状回的GMD显著降低，在右侧后扣带回皮质、中央后回皮质、双侧中央前回皮质和顶下小叶的GMD显著增加。与未患PTSD的VoR相比，患有PTSD的VoR在右侧钩回、左侧颞中回和梭状回的GMD显著降低，在左侧中央前回皮质、顶下小叶和右侧中央后回皮质的GMD增加。
患有PTSD的VoR中GMD异常的研究结果支持了PTSD与大脑广泛解剖学变化相关的假设。内侧额叶皮质、中央前回皮质、后扣带回皮质、中央后回皮质和顶下小叶可能在PTSD的神经病理学中起重要作用。
