Klaming Ruth, Harlé Katia M, Infante M Alejandra, Bomyea Jessica, Kim Charles, Spadoni Andrea D
VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.
Neurobiol Stress. 2018 Sep 27;10:100132. doi: 10.1016/j.ynstr.2018.09.009. eCollection 2019 Feb.
The considerable comorbidity of posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) poses a greater public health burden than either condition alone. Although there is a substantial body of evidence linking the direct neurotoxic effect of heavy drinking to gray matter (GM) deficits, as well as a growing body of literature supporting a strong association between PTSD and GM alterations, there is scant research interrogating the direct interaction of the two disorders. In order to generate data-driven, specific hypotheses regarding the overlapping neural substrates of PTSD and AUD, we conducted a meta-analysis of GM volumes in each disorder relative to healthy control subjects. We found shared GM deficits in the anterior cingulate cortex (ACC) across both disorders relative to healthy control participants. These findings suggest that reduced volumes of the ACC across PTSD and AUD may have implications for the development, expression, or treatment of symptoms linked to these frequently co-existing disorders. Recommendations are made for future work aimed at delineating the specific and shared effects of traumatic stress and alcoholism on neural integrity.
创伤后应激障碍（PTSD）与酒精使用障碍（AUD）的大量共病所带来的公共卫生负担，比这两种疾病单独造成的负担更大。尽管有大量证据表明大量饮酒的直接神经毒性作用与灰质（GM）缺陷有关，而且越来越多的文献支持PTSD与GM改变之间存在密切关联，但很少有研究探讨这两种疾病的直接相互作用。为了生成关于PTSD和AUD重叠神经基质的数据驱动的具体假设，我们对每种疾病相对于健康对照受试者的GM体积进行了荟萃分析。我们发现，相对于健康对照参与者，两种疾病在前扣带回皮质（ACC）均存在共同的GM缺陷。这些发现表明，PTSD和AUD患者ACC体积减小可能对与这些经常共存疾病相关的症状的发生、表现或治疗产生影响。针对未来旨在描绘创伤应激和酗酒对神经完整性的特定和共同影响的工作提出了建议。
