与5-羟色氨酸相关的反复性似曾相识感。
Recurring déjà vu associated with 5-hydroxytryptophan.
作者信息
Kalra Seema, Chancellor Andrew, Zeman Adam
机构信息
1Department of Neurology, Newcastle General Hospital, Newcastle, UK.
2Department of Neurology, Bay of Plenty District Health Board, Tauranga, New Zealand.
出版信息
Acta Neuropsychiatr. 2007 Oct;19(5):311-3. doi: 10.1111/j.1601-5215.2007.00245.x.
BACKGROUND
Déjà vu occurs both in normal experience and as a neuropsychiatric symptom. Its pathogenesis is partially understood. We describe an iatrogenic case with implications for the neuropharmacological basis of déjà vu.
CASE PRESENTATION
A 42-year-old woman received 5-hydroxytryptophan, in combination with carbidopa, as treatment for palatal tremor, on two occasions, separated by 1 week. On each occasion, she experienced intense, protracted déjà vu, lasting for several hours. We discuss her case in relation to the neuroanatomical and neuropharmacological basis of déjà vu.
CONCLUSION
The serotonergic system is involved in the genesis of déjà vu.
背景
既视感在正常体验中以及作为一种神经精神症状均会出现。其发病机制已部分为人所知。我们描述了一例医源性病例，该病例对既视感的神经药理学基础具有启示意义。
病例报告
一名42岁女性两次接受5-羟色氨酸联合卡比多巴治疗腭部震颤，两次治疗间隔1周。每次治疗时，她都经历了强烈且持久的既视感，持续数小时。我们结合既视感的神经解剖学和神经药理学基础对她的病例进行了讨论。
结论
血清素能系统参与了既视感的发生。
Zotero 插件