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Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015.2015 年丹麦血流感染患者和进口鸡肉中携带 mcr-1 编码质粒的耐黏菌素大肠杆菌的检测
Euro Surveill. 2015;20(49). doi: 10.2807/1560-7917.ES.2015.20.49.30085.
2
Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.中国动物和人类中出现的质粒介导的粘菌素耐药机制 MCR-1：微生物学和分子生物学研究。
Lancet Infect Dis. 2016 Feb;16(2):161-8. doi: 10.1016/S1473-3099(15)00424-7. Epub 2015 Nov 19.
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Effect of carbonyl cyanide 3-chlorophenylhydrazone (CCCP) on killing Acinetobacter baumannii by colistin.羰基氰化物 3-氯苯腙（CCCP）对黏菌素杀灭鲍曼不动杆菌的影响。
J Microbiol. 2015 Jan;53(1):53-9. doi: 10.1007/s12275-015-4498-5. Epub 2015 Jan 4.
4
Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria.多粘菌素耐药机制：细菌中的获得性耐药和固有耐药
Front Microbiol. 2014 Nov 26;5:643. doi: 10.3389/fmicb.2014.00643. eCollection 2014.
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Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies.鲍曼不动杆菌的黏菌素耐药性：临床报告、机制及抗菌策略
J Antimicrob Chemother. 2012 Jul;67(7):1607-15. doi: 10.1093/jac/dks084. Epub 2012 Mar 22.
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Resistance to polymyxins: Mechanisms, frequency and treatment options.对多黏菌素的耐药性：机制、频率和治疗选择。
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外排泵抑制剂对多重耐药革兰氏阴性菌中黏菌素耐药性的影响

Effects of Efflux Pump Inhibitors on Colistin Resistance in Multidrug-Resistant Gram-Negative Bacteria.

作者信息

Ni Wentao, Li Yanjun, Guan Jie, Zhao Jin, Cui Junchang, Wang Rui, Liu Youning

机构信息

Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing, China.

Department of Clinical Laboratory, Navy General Hospital, Beijing, China.

出版信息

Antimicrob Agents Chemother. 2016 Apr 22;60(5):3215-8. doi: 10.1128/AAC.00248-16. Print 2016 May.

DOI:10.1128/AAC.00248-16
PMID:26953203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4862505/
Abstract

We tested the effects of various putative efflux pump inhibitors on colistin resistance in multidrug-resistant Gram-negative bacteria. Addition of 10 mg/liter cyanide 3-chlorophenylhydrazone (CCCP) to the test medium could significantly decrease the MICs of colistin-resistant strains. Time-kill assays showed CCCP could reverse colistin resistance and inhibit the regrowth of the resistant subpopulation, especially in Acinetobacter baumannii and Stenotrophomonas maltophilia These results suggest colistin resistance in Gram-negative bacteria can be suppressed and reversed by CCCP.

摘要

我们测试了多种假定的外排泵抑制剂对多重耐药革兰氏阴性菌中黏菌素耐药性的影响。向测试培养基中添加10毫克/升的氰化物3-氯苯腙（CCCP）可显著降低耐黏菌素菌株的最低抑菌浓度（MIC）。时间杀菌试验表明，CCCP可逆转黏菌素耐药性并抑制耐药亚群的再生长，尤其是在鲍曼不动杆菌和嗜麦芽窄食单胞菌中。这些结果表明，革兰氏阴性菌中的黏菌素耐药性可被CCCP抑制和逆转。