Kim Dong Hwan, Yoo Seung Don, Chon Jinmann, Yun Dong Hwan, Kim Hee-Sang, Park Hae Jeong, Kim Su Kang, Chung Joo-Ho, Kang Jin Kyu, Lee Seung Ah
Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University, Seoul, Korea .
Kohwang Medical Research Institute, Kyung Hee University, Seoul, Korea .
J Korean Med Sci. 2016 Mar;31(3):430-4. doi: 10.3346/jkms.2016.31.3.430. Epub 2016 Feb 16.
To investigate the contribution of the interleukin-6 receptor (IL-6R) gene single nucleotide polymorphisms (SNPs) to the neurological status of Korean patients with ischemic stroke (IS), two SNPs of the IL-6R gene (rs4845617, 5 UTR; rs2228144, Ala31Ala) were selected. IS patients were classified into clinical phenotypes according to two well-defined scores: the National Institutes of Health Stroke Survey (NIHSS) and the Modified Barthel Index scores. There were 121 IS patients and 291 control subjects. The SNP rs4845617 significantly contributed to the neurological status of patients with IS (P = 0.011 in codominant model 2, P = 0.006 in recessive model, and P = 0.008 in log-additive model). Allele frequencies of rs4845617 and rs2228144 demonstrated no significant difference in IS patients and controls. The AG and GG haplotypes differed between the NIHSS 1 (NIHSS scores < 6) group and the NIHSS 2 (NIHSS scores ≥ 6) group in patients with IS (P = 0.014, P = 0.0024). These results suggest that rs4845617 of the IL-6R gene is associated with the neurologic status of Korean patients with IS.
为了研究白细胞介素-6受体（IL-6R）基因单核苷酸多态性（SNP）对韩国缺血性脑卒中（IS）患者神经状态的影响，选取了IL-6R基因的两个SNP（rs4845617，5'UTR；rs2228144，Ala31Ala）。根据两个明确的评分标准将IS患者分为临床表型：美国国立卫生研究院卒中量表（NIHSS）和改良巴氏指数评分。共有121例IS患者和291例对照受试者。SNP rs4845617对IS患者的神经状态有显著影响（共显性模型2中P = 0.011，隐性模型中P = 0.006，对数加性模型中P = 0.008）。rs4845617和rs2228144的等位基因频率在IS患者和对照中无显著差异。IS患者中，NIHSS 1（NIHSS评分<6）组和NIHSS 2（NIHSS评分≥6）组间的AG和GG单倍型存在差异（P = 0.014，P = 0.0024）。这些结果表明，IL-6R基因的rs4845617与韩国IS患者的神经状态相关。
