Tabur Suzan, Oztuzcu Serdar, Oguz Elif, Demiryürek Seniz, Dagli Hasan, Alasehirli Belgin, Ozkaya Mesut, Demiryürek Abdullah T
Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, 27310, Gaziantep, Turkey.
Department of Medical Biology, Faculty of Medicine, University of Gaziantep, 27310, Gaziantep, Turkey.
Endocrine. 2016 Aug;53(2):465-70. doi: 10.1007/s12020-016-0910-0. Epub 2016 Mar 8.
The metabolic syndrome (MetS) is a common multicomponent condition including abdominal obesity, dyslipidemia, hypertension, and hyperglycaemia. The aim of this study was to investigate the associations of the expression of a panel of signalling genes with the MetS in a Turkish population. A total of 54 MetS patients and 42 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a BioMark 96.96 dynamic array system. We observed marked increases in LIM kinase 2 (LIMK2) and cofilin 1 (CFL1) gene expressions in MetS patients. However, there were significant decreases in intercellular adhesion molecules 1 (ICAM1), ezrin (EZR), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3) gene expressions in MetS patients. Additionally, no marked changes were noted in other 15 genes studied. This is the first study to provide evidence that activation of LIMK2/CFL1 pathway may play an important role in MetS.
代谢综合征（MetS）是一种常见的多组分病症，包括腹型肥胖、血脂异常、高血压和高血糖。本研究的目的是调查一组信号基因的表达与土耳其人群中代谢综合征的关联。本研究共纳入了54例代谢综合征患者和42例年龄和性别相似的健康对照。从血样中提取mRNA，并使用BioMark 96.96动态阵列系统对基因表达进行实时聚合酶链反应。我们观察到代谢综合征患者中LIM激酶2（LIMK2）和丝切蛋白1（CFL1）基因表达显著增加。然而，代谢综合征患者中细胞间黏附分子1（ICAM1）、埃兹蛋白（EZR）、丝裂原活化蛋白激酶激酶2（MAP2K2）和一氧化氮合酶3（NOS3）基因表达显著降低。此外，在所研究的其他15个基因中未观察到明显变化。这是第一项提供证据表明LIMK2/CFL1途径的激活可能在代谢综合征中起重要作用的研究。
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