Kaux Jean-François, Samson Antoine, Crielaard Jean-Michel
Department of Physical Medicine and Sports Traumatology, CHU Liège, Belgium; Multidisciplinary Department for Medicine and Sports Traumatology (SPORTS), CHU Liège, Belgium; Department of Sports and Rehabilitation Sciences, University of Liège, Belgium.
Department of Physical Medicine and Sports Traumatology, CHU Liège, Belgium; Multidisciplinary Department for Medicine and Sports Traumatology (SPORTS), CHU Liège, Belgium.
Muscles Ligaments Tendons J. 2016 Feb 13;5(4):264-9. doi: 10.11138/mltj/2015.5.4.264. eCollection 2015 Oct-Dec.
recently, the viscoelastic properties of hyaluronic acid (HA) on liquid connective tissue have been proposed for the treatment of tendinopathies. Some fundamental studies show encouraging results on hyaluronic acid's ability to promote tendon gliding and reduce adhesion as well as to improve tendon architectural organisation. Some observations also support its use in a clinical setting to improve pain and function. This literature review analyses studies relating to the use of hyaluronic acid in the treatment of tendinopathies.
this review was constructed using the Medline database via Pubmed, Scopus and Google Scholar. The key words hyaluronic acid, tendon and tendinopathy were used for the research.
in total, 28 articles (in English and French) on the application of hyaluronic acid to tendons were selected for their relevance and scientific quality, including 13 for the in vitro part, 7 for the in vivo animal part and 8 for the human section.
preclinical studies demonstrate encouraging results: HA permits tendon gliding, reduces adhesions, creates better tendon architectural organisation and limits inflammation. These laboratory observations appear to be supported by limited but encouraging short-term clinical results on pain and function. However, controlled randomised studies are still needed.
最近，有人提出利用透明质酸（HA）对液体结缔组织的粘弹性特性来治疗肌腱病。一些基础研究表明，透明质酸在促进肌腱滑动、减少粘连以及改善肌腱结构组织方面的能力取得了令人鼓舞的结果。一些观察结果也支持其在临床环境中用于改善疼痛和功能。这篇文献综述分析了与使用透明质酸治疗肌腱病相关的研究。
本综述通过PubMed、Scopus和谷歌学术使用Medline数据库构建。关键词“透明质酸”“肌腱”和“肌腱病”用于此项研究。
总共筛选出28篇（英文和法文）关于透明质酸应用于肌腱的文章，因其相关性和科学质量，其中13篇用于体外部分，7篇用于体内动物部分，8篇用于人体部分。
临床前研究显示出令人鼓舞的结果：透明质酸可使肌腱滑动、减少粘连、形成更好的肌腱结构组织并减轻炎症。这些实验室观察结果似乎得到了关于疼痛和功能的有限但令人鼓舞的短期临床结果的支持。然而，仍需要进行对照随机研究。
