Wang Juan, Yang Deyu, Yu Yu, Shao Gaohai, Wang Qunbo
Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing 404100, China.
Department of Orthopedics, Yongchuan Hospital of Chongqing Medical University, Chongqing 404100, China.
Nutrients. 2016 Mar 4;8(3):142. doi: 10.3390/nu8030142.
Circulating vitamin D has previously been found to be lower in patients with Parkinson's disease (PD), while the effects of sunlight exposure have not yet been fully investigated. Therefore, we evaluated the associations between serum vitamin D, vitamin D intake, sunlight exposure, and newly-diagnosed PD patients in a Chinese population. This case-control study measured serum 25-hydroxyvitamin D (25(OH)D) levels and sunlight exposure in 201 patients with newly-diagnosed PD and 199 controls without neurodegenerative diseases. Data on vitamin D intake and sunlight exposure were obtained using a self-report questionnaire. Multivariable logistic regressions were employed to evaluate the associations between serum 25(OH)D levels, sunlight exposure, and PD. Adjustments were made for sex, age, smoking, alcohol use, education, BMI, and vitamin D intake. There were significantly lower levels of serum 25(OH)D (20.6 ± 6.5 ng/mL), daily vitamin D intake (8.3 ± 3.7 g/day), and sunlight exposure (9.7 ± 4.1 h/week) in patients with PD compared to healthy controls (p < 0.05). Crude odds ratios (ORs) for PD in the quartiles of serum 25(OH)D were 1 (reference), 0.710 (0.401, 1.257), 0.631 (0.348, 1.209), and 0.483 (0.267, 0.874), respectively. Crude ORs for PD in quartiles of sunlight exposure were 1 (reference), 0.809 (0.454, 1.443), 0.623 (0.345, 1.124) and 0.533 (0.294, 0.966), respectively. A significant positive correlation between serum 25(OH)D and sunlight exposure was found, but serum 25(OH)D was not correlated with daily vitamin D intake. This study indicates that lower levels of serum 25(OH)D and sunlight exposure are significantly associated with an increased risk for PD.
此前发现帕金森病（PD）患者的循环维生素D水平较低，而阳光照射的影响尚未得到充分研究。因此，我们评估了中国人群中血清维生素D、维生素D摄入量、阳光照射与新诊断的PD患者之间的关联。这项病例对照研究测量了201例新诊断的PD患者和199例无神经退行性疾病的对照者的血清25-羟基维生素D（25(OH)D）水平和阳光照射情况。维生素D摄入量和阳光照射的数据通过自我报告问卷获得。采用多变量逻辑回归来评估血清25(OH)D水平、阳光照射与PD之间的关联。对性别、年龄、吸烟、饮酒、教育程度、体重指数和维生素D摄入量进行了调整。与健康对照者相比，PD患者的血清25(OH)D水平（20.6±6.5 ng/mL）、每日维生素D摄入量（8.3±3.7μg/天）和阳光照射时间（9.7±4.1小时/周）显著更低（p<0.05）。血清25(OH)D四分位数中PD的粗比值比（OR）分别为1（参照）、0.710（0.401，1.257）、0.631（0.348，1.209）和0.483（0.267，0.874）。阳光照射四分位数中PD的粗OR分别为1（参照）、0.809（0.454，1.443）、0.623（0.345，1.124）和0.533（0.294，0.966）。发现血清25(OH)D与阳光照射之间存在显著正相关，但血清25(OH)D与每日维生素D摄入量无相关性。这项研究表明，血清25(OH)D水平降低和阳光照射不足与PD风险增加显著相关。
