Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, China.
Acta Neurol Scand. 2019 Oct;140(4):274-280. doi: 10.1111/ane.13141. Epub 2019 Aug 6.
Vitamin D deficiency is widespread in patients with Parkinson's disease (PD). Our aim was to determine whether serum vitamin D levels correlated with bone mineral density (BMD) and non-motor symptoms in patients with PD.
MATERIALS & METHODS: A consecutive series of 182 patients with PD and 185 healthy controls were included. Serum 25-hydroxyvitamin D (25[OH]D) levels were measured by immunoassay, while BMD of the lumbar spine and femoral neck was measured by dual-energy X-ray absorptiometry. Associations between serum vitamin D levels and clinical data were evaluated using partial correlation analysis.
Patients with PD had significantly lower serum 25(OH)D levels relative to healthy controls (49.75 ± 14.11 vs 43.40 ± 16.51, P < 0.001). Furthermore, PD patients with lower vitamin D levels had a significantly higher frequency of falls (P = 0.033) and insomnia (P = 0.015). They also had significantly higher scores for the Pittsburgh Sleep Quality Index (PSQI; P = 0.014), depression (P = 0.020), and anxiety (P = 0.009). Finally, patients with PD also had a significantly lower mean BMD of the lumbar spine (P = 0.011) and femoral neck (P < 0.001). After adjusting for age, sex, and body mass index, vitamin D levels significantly correlated with falls, insomnia, and scores for the PSQI, depression, and anxiety.
In patients with PD, vitamin D levels significantly correlated with falls and some non-motor symptoms. However, no associations were found between BMD and the serum 25(OH)D levels in patients with PD. Thus, vitamin D supplementation is a potential therapeutic for non-motor PD symptoms.
维生素 D 缺乏在帕金森病（PD）患者中普遍存在。我们的目的是确定 PD 患者的血清维生素 D 水平是否与骨密度（BMD）和非运动症状相关。
连续纳入 182 例 PD 患者和 185 例健康对照者。采用免疫分析法测定血清 25-羟维生素 D（25[OH]D）水平，双能 X 线吸收法测定腰椎和股骨颈 BMD。采用偏相关分析评估血清维生素 D 水平与临床资料之间的相关性。
PD 患者的血清 25（OH）D 水平显著低于健康对照组（49.75±14.11 比 43.40±16.51，P<0.001）。此外，维生素 D 水平较低的 PD 患者发生跌倒的频率更高（P=0.033），失眠更严重（P=0.015）。他们的匹兹堡睡眠质量指数（PSQI）评分（P=0.014）、抑郁评分（P=0.020）和焦虑评分（P=0.009）也更高。最后，PD 患者的腰椎（P=0.011）和股骨颈（P<0.001）BMD 也显著较低。在校正年龄、性别和体重指数后，维生素 D 水平与跌倒、失眠和 PSQI、抑郁和焦虑评分显著相关。
在 PD 患者中，维生素 D 水平与跌倒和一些非运动症状显著相关。然而，PD 患者的 BMD 与血清 25（OH）D 水平之间未发现相关性。因此，维生素 D 补充可能是治疗 PD 非运动症状的一种潜在方法。
