Genetic Variability of the Vitamin D Receptor Affects Susceptibility to Parkinson's Disease and Dopaminergic Treatment Adverse Events.

Vitamin D is a lipid-soluble molecule and an important transcriptional regulator in many tissues and organs, including the brain. Its role has been demonstrated also in Parkinson's disease (PD) pathogenesis. Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade. The aim of this study was to assess the associations of genetic variability with PD risk and different PD-related phenotypes. We genotyped 231 well characterized PD patients and 161 healthy blood donors for six single nucleotide polymorphisms, namely rs739837, rs4516035, rs11568820, rs731236, rs2228570, and rs1544410. We observed that rs2228570 is associated with PD risk ( < 0.001). Additionally, we observed associations of specific genotypes with adverse events of dopaminergic treatment. rs1544410 (GG vs. GA + AA: = 0.005; GG vs. GA: = 0.009) was associated with the occurrence of visual hallucinations and rs739837 (TT vs. GG: = 0.036), rs731236 (TT vs. TC + CC: = 0.011; TT vs. TC: = 0.028; TT vs. CC: = 0.035), and rs1544410 (GG vs. GA: = 0.014) with the occurrence of orthostatic hypotension. We believe that the reported study may support personalized approach to PD treatment, especially in terms of monitoring vitamin D level and vitamin D supplementation in patients with high risk genotypes.