治疗甲状腺疾病不止一种方法。采用每周肌肉注射左甲状腺素治疗小儿甲状腺功能减退症。
More than one way to skin a thyroid. Managing pediatric hypothyroidism with weekly intramuscular levothyroxine.
作者信息
Alba Patria, Mitre Naim, Feldt Max
出版信息
J Pediatr Endocrinol Metab. 2016 Jun 1;29(6):745-8. doi: 10.1515/jpem-2015-0382.
BACKGROUND
Oral levothyroxine (L-T4) supplementation is usually an effective therapy in pediatric hypothyroidism, except in patients with malabsorption or pseudomalabsorption. In these cases, parenteral L-T4 may be required, but there is a paucity of information about this delivery method in the pediatric population.
CASE PRESENTATION
We present three cases of pediatric patients with primary hypothryoidism unresponsive to oral L-T4 that were successfully treated with intramuscular (IM) L-T4.
CONCLUSIONS
This is the first pediatric case series of successful IM L-T4 therapy in refractory primary hypothyroidism. Our case series demonstrates that once weekly IM L-T4 dosing may be a safe and well tolerated treatment regimen for pediatric patients.
背景
口服左甲状腺素（L-T4）补充治疗通常是小儿甲状腺功能减退症的有效疗法，但吸收不良或假性吸收不良的患者除外。在这些情况下，可能需要胃肠外给予L-T4，但关于小儿人群中这种给药方式的信息较少。
病例报告
我们报告了3例原发性甲状腺功能减退症小儿患者，口服L-T4治疗无效，经肌肉注射（IM）L-T4成功治疗。
结论
这是难治性原发性甲状腺功能减退症中成功进行IM L-T4治疗的首个小儿病例系列。我们的病例系列表明，每周一次IM L-T4给药可能是小儿患者安全且耐受性良好的治疗方案。
Zotero 插件