Karolewicz Bożena, Nartowski Karol, Pluta Janusz, Górniak Agata
Acta Pharm. 2016 Mar;66(1):119-28. doi: 10.1515/acph-2016-0008.
The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and chemical interactions between the drug and polymer using FTIR spectral studies, differential scanning calorimetry and powder X-ray diffraction analysis. The dissolution rate of acyclovir was determined using the rotating disk method. It was found that the minimal content of the polymer within the mixtures needed to increase the dissolution rate of the drug was 50 %.
通过采用捏合方法，以不同的药物与聚合物比例制备阿昔洛韦与非离子聚合物泊洛沙姆F127的物理混合物和固体分散体，提高了无水阿昔洛韦的溶出速率。使用傅里叶变换红外光谱研究、差示扫描量热法和粉末X射线衍射分析，对所得物理混合物和固体分散体的药物含量以及药物与聚合物之间可能的物理和化学相互作用进行了检测。采用旋转圆盘法测定阿昔洛韦的溶出速率。结果发现，混合物中提高药物溶出速率所需聚合物的最低含量为50%。
