Agustí Jaime, Peñas Lucas, Bosch Nuria
Department of Pathology, Consorcio Hospitalario Provincial de Castellón, Castellón, Spain.
Am J Dermatopathol. 2016 Jul;38(7):546-8. doi: 10.1097/DAD.0000000000000522.
Myopericytoma is a perivascular myoid neoplasm of skin and soft tissues characterized by numerous thin-walled blood vessels surrounded concentrically by round to spindle myoid tumor cells, which shows α-smooth muscle actin and h-caldesmon coexpression and commonly negativity for desmin. These tumors arise predominantly in extremities of adult patients with benign clinical course. Based on the architectural pattern, there are various histologic variants as classical-solid myopericytoma, hemangiopericytoma-like myopericytoma, angioleiomyoma-like myopericytoma, myofibroma-like myopericytoma, hipocelular fibroma-like myopericytoma, intravascular myopericytoma, cellular immature myopericytoma, and malignant myopericytoma. The authors report a case that fully satisfies the morphological and immunohistochemical criteria for intravascular myopericytoma, which plantar location is not previously described in the literature. In addition, the authors discuss about its possible development from a preexistent cutaneous vascular malformation.
肌周细胞瘤是一种皮肤和软组织的血管周围肌样肿瘤，其特征是众多薄壁血管被圆形至梭形肌样肿瘤细胞同心环绕，这些肿瘤细胞显示α-平滑肌肌动蛋白和h-钙调蛋白共表达，且结蛋白通常为阴性。这些肿瘤主要发生于成年患者的四肢，临床过程良性。根据结构模式，有多种组织学变异型，如经典实性肌周细胞瘤、血管外皮瘤样肌周细胞瘤、血管平滑肌瘤样肌周细胞瘤、肌纤维瘤样肌周细胞瘤、细胞稀少纤维瘤样肌周细胞瘤、血管内肌周细胞瘤、细胞性未成熟肌周细胞瘤和恶性肌周细胞瘤。作者报告了一例完全符合血管内肌周细胞瘤形态学和免疫组化标准的病例，其足底部位此前未见文献报道。此外，作者讨论了其可能由先前存在的皮肤血管畸形发展而来。
