Flank Jacqueline, Robinson Paula D, Holdsworth Mark, Phillips Robert, Portwine Carol, Gibson Paul, Maan Cathy, Stefin Nancy, Sung Lillian, Dupuis L Lee
Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada.
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
Pediatr Blood Cancer. 2016 Jul;63(7):1144-51. doi: 10.1002/pbc.25955. Epub 2016 Mar 9.
This clinical practice guideline provides an approach to the treatment of breakthrough chemotherapy-induced nausea and vomiting (CINV) and the prevention of refractory CINV in children. It was developed by an international, interprofessional panel and is based on systematic literature reviews. Evidence-based interventions for the treatment of breakthrough and prophylaxis of refractory CINV are recommended. Gaps in the evidence used to support the recommendations made in this clinical practice guideline were identified. The contribution of these recommendations to breakthrough and refractory CINV control in children requires prospective evaluation.
本临床实践指南提供了一种治疗儿童突破性化疗引起的恶心和呕吐（CINV）以及预防难治性CINV的方法。它由一个国际跨专业小组制定，基于系统的文献综述。推荐了基于证据的干预措施用于治疗突破性CINV和预防难治性CINV。本临床实践指南中所提建议所依据的证据存在差距。这些建议对儿童突破性和难治性CINV控制的贡献需要进行前瞻性评估。
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