Aydemir Esra
Department of Biomedical Engineering, Biruni University, Istanbul, 34010, Turkey.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec 14. doi: 10.1007/s00210-024-03715-2.
Metoclopramide HCl is the active ingredient of the commonly used drugs against nausea, heartburn, and acid reflux. Other than the patients with the acid reflux and stomach problems, it has been widely used in patients going through chemotherapy and radiotherapy, as well as patients suffering from migraine with stomach issues. To our knowledge, the immunomodulatory effect of metoclopramide HCl has never been tested extensively. Since patients who are going through chemotherapy and radiotherapy are prone to developing immunodeficiencies, it is imperative to analyze the activity of this active drug ingredient on the mammalian macrophages. For this purpose, the mammalian macrophages were tested for their potential to produce the pro-inflammatory cytokines, in vitro, in the presence and absence of LPS as the stimulating agent with a range of metoclopramide concentrations. Our results suggest that metoclopramide HCl did not stimulate the macrophages by itself; but in the presence of LPS stimulation, it significantly and substantially decreased the production of the pro-inflammatory TNFα, IL-6, GMCSF, and IL12p40 cytokines. Although this study involved solely in vitro model, the results imply that in the clinical setting metoclopramide HCl might induce inflammatory reaction against potential infections.
盐酸甲氧氯普胺是常用的抗恶心、胃灼热和胃酸反流药物的活性成分。除了患有胃酸反流和胃部问题的患者外，它还广泛应用于接受化疗和放疗的患者以及患有偏头痛且有胃部问题的患者。据我们所知，盐酸甲氧氯普胺的免疫调节作用从未得到广泛测试。由于接受化疗和放疗的患者容易出现免疫缺陷，因此有必要分析这种活性药物成分对哺乳动物巨噬细胞的活性。为此，在有和没有脂多糖作为刺激剂的情况下，使用一系列浓度的甲氧氯普胺在体外测试了哺乳动物巨噬细胞产生促炎细胞因子的潜力。我们的结果表明，盐酸甲氧氯普胺本身不会刺激巨噬细胞；但在脂多糖刺激存在的情况下，它会显著且大幅度地降低促炎细胞因子TNFα、IL - 6、GMCSF和IL12p40的产生。尽管这项研究仅涉及体外模型，但结果表明在临床环境中，盐酸甲氧氯普胺可能会引发针对潜在感染的炎症反应。
