Haraldsen Pernille, Metzsch Carsten, Lindstedt Sandra, Algotsson Lars, Ingemansson Richard
Department of Cardiothoracic Surgery, Anesthesia and Intensive Care, Skane University Hospital, Lund, Sweden.
Department of Cardiothoracic Surgery, Anesthesia and Intensive Care, Skane University Hospital, Lund, Sweden
Perfusion. 2016 Sep;31(6):495-502. doi: 10.1177/0267659116637134. Epub 2016 Mar 9.
The intention of the present study was to evaluate possible cardioprotective properties of inhalation anesthesia with sevoflurane.
A porcine, open-chest model of right ventricular ischemia was used in 7 pigs receiving inhalation anesthesia with sevoflurane. The model was earlier developed and published by our group, using pigs receiving intravenous anesthesia with propofol. They served as controls. The animals were observed for three hours after the induction of right ventricular ischemia by ligation of the main branches supplying the right ventricular free wall.
In the sevoflurane group, the cardiac output recovered 2 hours after the induction of ischemia and intact right ventricular stroke work was observed. In the propofol group, no such recovery occurred. The release of troponin T was significantly lower than in the sevoflurane group.
Inhalation anesthesia with sevoflurane seems superior to intravenous anesthesia with propofol in acute right ventricular ischemic dysfunction.
本研究旨在评估七氟醚吸入麻醉可能具有的心脏保护特性。
7头接受七氟醚吸入麻醉的猪采用了右心室缺血的开胸猪模型。该模型是我们团队之前使用接受丙泊酚静脉麻醉的猪开发并发表的。这些猪作为对照。在结扎供应右心室游离壁的主要分支诱导右心室缺血后，对动物进行3小时观察。
在七氟醚组中，缺血诱导后2小时心输出量恢复，且观察到右心室完整的搏功。在丙泊酚组中，未出现此类恢复。肌钙蛋白T的释放明显低于七氟醚组。
在急性右心室缺血性功能障碍方面，七氟醚吸入麻醉似乎优于丙泊酚静脉麻醉。
