Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan.
Food Funct. 2016 Apr;7(4):1941-9. doi: 10.1039/c6fo00078a.
Hyperglycemia, increased inflammatory responses, and dysregulation of mitochondrial function accompanied by type 2 diabetes may eventually lead to kidney damage. We examined the protective effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit and green tea, on kidney damage in diabetic db/db mice. Dietary oligonol supplementation lowered glucose and insulin levels and improved oral glucose tolerance. Oligonol attenuated serum resistin and IL-6 levels and reduced glomerular hypertrophy and mesangial matrix expansion caused by diabetes. Oligonol reduced activation of nuclear factor-kappa B (NF-κB) and p38 mitogen-activated protein kinase. Suppressed renal oxidative stress by oligonol was associated with stimulated sirtuin1 expression and restored AMP-activated kinase protein α activity, mitochondrial DNA copy number, and mitochondrial biogenesis associated genes including nuclear respiratory factor 1 and mitochondrial transcription factor A. In conclusion, oligonol reduced fasting glucose level, improved insulin sensitivity, suppressed inflammatory responses, and upregulated metabolic regulators involved in mitochondrial biogenesis, thereby leading to protection against diabetes-induced kidney damage.
高血糖、炎症反应增加和线粒体功能失调伴随着 2 型糖尿病，最终可能导致肾脏损伤。我们研究了低分子多酚聚乙二醇（oligonol），一种从荔枝和绿茶中提取的多酚，对 db/db 糖尿病小鼠肾脏损伤的保护作用。饮食补充聚乙二醇可降低血糖和胰岛素水平，并改善口服葡萄糖耐量。聚乙二醇可减轻糖尿病引起的血清抵抗素和白细胞介素 6 水平升高，并减少肾小球肥大和系膜基质扩张。聚乙二醇可减少核因子-κB（NF-κB）和 p38 丝裂原活化蛋白激酶的激活。聚乙二醇抑制肾脏氧化应激与刺激沉默信息调节因子 1 表达和恢复 AMP 激活的蛋白激酶 α 活性、线粒体 DNA 拷贝数以及与线粒体生物发生相关的基因有关，包括核呼吸因子 1 和线粒体转录因子 A。总之，聚乙二醇可降低空腹血糖水平，改善胰岛素敏感性，抑制炎症反应，并上调与线粒体生物发生相关的代谢调节剂，从而防止糖尿病引起的肾脏损伤。
