Wei X, Li Y, Zhang S, Li X, Gao M
Department of Thyroid and Cervical Tumor, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Indian J Cancer. 2015 Oct-Dec;52(4):546-50. doi: 10.4103/0019-509X.178419.
To evaluate the features of primary thyroid lymphoma (PTL) by ultrasonography (US) combined with contrast-enhanced ultrasonography (CEUS).
In this retrospective study, 20 patients (8 male and 12 female) with PTL were evaluated by conventional US and among them, 10 patients underwent CEUS examination. The appearance of US features was classified into three types: Diffusive mass type, multiple nodular type and mixed type. The CEUS patterns included diffusive homogeneous enhancement and diffusive heterogeneous enhancement pattern. Parameters of CEUS time-intensive curve were analyzed in primary tumor and involved lymph nodes compared to ipsilateral common carotid artery.
Of 20 patients with PTL, 18 presented an enlarging neck mass that grew rapidly with an average duration of 3.2 months, and 17 were associated with Hashimoto's thyroiditis. In conventional US, all patients had marked hypoechoic masses. Among them, 12 patients were diffusive mass type, 6 were multiple nodular type and 2 were mixed type. For CEUS patterns, 8 were diffusive homogeneous enhancement and 2 were diffusive heterogeneous enhancement. Necrosis areas were showed in diffuse heterogeneous pattern which were hardly seen in conventional US. In the quantitative analysis of CEUS parameters, the time to peak of time-intensive curve in the primary tumors or involved lymph nodes was longer than that of the ipsilateral common carotid artery (P = 0.004).
PTL mainly demonstrated as a diffusive mass type with marked hypoechogenecity on conventional US and diffusive homogeneous enhancement pattern on CEUS. And the heterogeneous enhancement pattern is also helpful for detecting necrosis areas of PTL.
通过超声（US）联合超声造影（CEUS）评估原发性甲状腺淋巴瘤（PTL）的特征。
在这项回顾性研究中，对20例PTL患者（8例男性和12例女性）进行了常规超声评估，其中10例患者接受了CEUS检查。超声特征表现分为三种类型：弥漫性肿块型、多发结节型和混合型。CEUS模式包括弥漫性均匀增强和弥漫性不均匀增强模式。将原发性肿瘤和受累淋巴结的CEUS时间强度曲线参数与同侧颈总动脉进行比较分析。
20例PTL患者中，18例表现为颈部肿块增大，生长迅速，平均病程3.2个月，17例与桥本甲状腺炎有关。在常规超声检查中，所有患者均有明显低回声肿块。其中，弥漫性肿块型12例，多发结节型6例，混合型2例。CEUS模式方面，弥漫性均匀增强8例，弥漫性不均匀增强2例。弥漫性不均匀模式显示有坏死区域，这在常规超声中很难看到。在CEUS参数的定量分析中，原发性肿瘤或受累淋巴结的时间强度曲线达峰时间长于同侧颈总动脉（P = 0.004）。
PTL在常规超声上主要表现为弥漫性肿块型，回声明显减低，在CEUS上表现为弥漫性均匀增强模式。不均匀增强模式也有助于检测PTL的坏死区域。
