Dogliotti L, Orlandi F, Angeli A
World J Surg. 1989 Nov-Dec;13(6):674-9. doi: 10.1007/BF01658413.
There is sound clinical evidence that many benign breast conditions, especially pain, nodularity, and cysts, are likely to have their pathogenesis in hormonal events during reproductive life. Yet the classical theories of persisting hyperestrogenism and luteal progestogen deficiency have not stood up to detailed investigation. Recent work has demonstrated the importance of dynamic hormonal changes and of chronobiological rhythms--daily, menstrual, and seasonal. Recent developments and findings are reviewed to point to the directions in which the basic etiology of these conditions is likely to be discovered.
有可靠的临床证据表明，许多良性乳腺疾病，尤其是疼痛、结节和囊肿，其发病机制可能与生殖期的激素变化有关。然而，经典的雌激素持续过多和黄体期孕激素缺乏理论并未经得住详细研究的检验。最近的研究表明，动态激素变化以及每日、月经周期和季节的生物钟节律具有重要意义。本文综述了最新的进展和发现，以指出这些疾病基本病因可能的研究方向。
